Early extubation with immediate non-invasive ventilation versus standard weaning in intubated patients for coronavirus disease 2019: a retrospective multicenter study.
Sci Rep
; 11(1): 13418, 2021 06 28.
文章
在 英语
| MEDLINE | ID: covidwho-1286475
ABSTRACT
In patients intubated for hypoxemic acute respiratory failure (ARF) related to novel coronavirus disease (COVID-19), we retrospectively compared two weaning strategies, early extubation with immediate non-invasive ventilation (NIV) versus standard weaning encompassing spontaneous breathing trial (SBT), with respect to IMV duration (primary endpoint), extubation failures and reintubations, rate of tracheostomy, intensive care unit (ICU) length of stay and mortality (additional endpoints). All COVID-19 adult patients, intubated for hypoxemic ARF and subsequently extubated, were enrolled. Patients were included in two groups, early extubation followed by immediate NIV application, and conventionally weaning after passing SBT. 121 patients were enrolled and analyzed, 66 early extubated and 55 conventionally weaned after passing an SBT. IMV duration was 9 [6-11] days in early extubated patients versus 11 [6-15] days in standard weaning group (p = 0.034). Extubation failures [12 (18.2%) vs. 25 (45.5%), p = 0.002] and reintubations [12 (18.2%) vs. 22 (40.0%) p = 0.009] were fewer in early extubation compared to the standard weaning groups, respectively. Rate of tracheostomy, ICU mortality, and ICU length of stay were no different between groups. Compared to standard weaning, early extubation followed by immediate NIV shortened IMV duration and reduced the rate of extubation failure and reintubation.
全文:
可用
采集:
国际数据库
资料库:
MEDLINE
主要主题:
Ventilator Weaning
/
Noninvasive Ventilation
/
COVID-19
研究类型:
实验研究
/
观察性研究
/
预后研究
/
随机对照试验
限制:
年老的
/
女性
/
人类
/
男性
/
中年
语言:
英语
期刊:
Sci Rep
年:
2021
类型:
文章
所属国家:
S41598-021-92960-z
相关文档
MEDLINE
...
LILACS
LIS