In-hospital mortality among immunosuppressed patients with COVID-19: Analysis from a national cohort in Spain.
PLoS One
; 16(8): e0255524, 2021.
文章
在 英语
| MEDLINE | ID: covidwho-1339412
ABSTRACT
BACKGROUND:
Whether immunosuppressed (IS) patients have a worse prognosis of COVID-19 compared to non-IS patients is not known. The aim of this study was to evaluate the clinical characteristics and outcome of IS patients hospitalized with COVID-19 compared to non-IS patients.METHODS:
We designed a retrospective cohort study. We included all patients hospitalized with laboratory-confirmed COVID-19 from the SEMI-COVID-19 Registry, a large multicentre national cohort in Spain, from March 27th until June 19th, 2020. We used multivariable logistic regression to assess the adjusted odds ratios (aOR) of in-hospital death among IS compared to non-IS patients.RESULTS:
Among 13 206 included patients, 2 111 (16.0%) were IS. A total of 166 (1.3%) patients had solid organ (SO) transplant, 1081 (8.2%) had SO neoplasia, 332 (2.5%) had hematologic neoplasia, and 570 (4.3%), 183 (1.4%) and 394 (3.0%) were receiving systemic steroids, biological treatments, and immunosuppressors, respectively. Compared to non-IS patients, the aOR (95% CI) for in-hospital death was 1.60 (1.43-1.79) for all IS patients, 1.39 (1.18-1.63) for patients with SO cancer, 2.31 (1.76-3.03) for patients with haematological cancer and 3.12 (2.23-4.36) for patients with SO transplant. The aOR (95% CI) for death for patients who were receiving systemic steroids, biological treatments and immunosuppressors compared to non-IS patients were 2.16 (1.80-2.61), 1.97 (1.33-2.91) and 2.06 (1.64-2.60), respectively. IS patients had a higher odds than non-IS patients of in-hospital acute respiratory distress syndrome, heart failure, myocarditis, thromboembolic disease and multiorgan failure.CONCLUSIONS:
IS patients hospitalized with COVID-19 have a higher odds of in-hospital complications and death compared to non-IS patients.
全文:
可用
采集:
国际数据库
资料库:
MEDLINE
主要主题:
Hospital Mortality
/
COVID-19
研究类型:
队列研究
/
实验研究
/
观察性研究
/
预后研究
/
随机对照试验
话题:
长Covid
/
变体
限制:
年老的
/
女性
/
人类
/
男性
/
中年
国家/地区名称主题:
欧罗巴
语言:
英语
期刊:
PLoS One
期刊主题:
科学
/
医学
年:
2021
类型:
文章
所属国家:
Journal.pone.0255524
相关文档
MEDLINE
...
LILACS
LIS