Risk of COVID-19 death in cancer patients: an analysis from Guy's Cancer Centre and King's College Hospital in London.
Br J Cancer
; 125(7): 939-947, 2021 09.
文章
在 英语
| MEDLINE | ID: covidwho-1360191
ABSTRACT
BACKGROUND:
Using an updated dataset with more patients and extended follow-up, we further established cancer patient characteristics associated with COVID-19 death.METHODS:
Data on all cancer patients with a positive reverse transcription-polymerase chain reaction swab for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) at Guy's Cancer Centre and King's College Hospital between 29 February and 31 July 2020 was used. Cox proportional hazards regression was performed to identify which factors were associated with COVID-19 mortality.RESULTS:
Three hundred and six SARS-CoV-2-positive cancer patients were included. Seventy-one had mild/moderate and 29% had severe COVID-19. Seventy-two patients died of COVID-19 (24%), of whom 35 died <7 days. Male sex [hazard ratio (HR) 1.97 (95% confidence interval (CI) 1.15-3.38)], Asian ethnicity [3.42 (1. 59-7.35)], haematological cancer [2.03 (1.16-3.56)] and a cancer diagnosis for >2-5 years [2.81 (1.41-5.59)] or ≥5 years were associated with an increased mortality. Age >60 years and raised C-reactive protein (CRP) were also associated with COVID-19 death. Haematological cancer, a longer-established cancer diagnosis, dyspnoea at diagnosis and raised CRP were indicative of early COVID-19-related death in cancer patients (<7 days from diagnosis).CONCLUSIONS:
Findings further substantiate evidence for increased risk of COVID-19 mortality for male and Asian cancer patients, and those with haematological malignancies or a cancer diagnosis >2 years. These factors should be accounted for when making clinical decisions for cancer patients.
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采集:
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资料库:
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主要主题:
Hematologic Neoplasms
/
SARS-CoV-2
/
COVID-19
/
Neoplasms
研究类型:
队列研究
/
观察性研究
/
预后研究
话题:
长Covid
限制:
成人
/
年老的
/
女性
/
人类
/
男性
/
中年
国家/地区名称主题:
欧罗巴
语言:
英语
期刊:
Br J Cancer
年:
2021
类型:
文章
所属国家:
S41416-021-01500-z
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