The nano delivery systems and applications of mRNA.
Eur J Med Chem
; 227: 113910, 2022 Jan 05.
文章
在 英语
| MEDLINE | ID: covidwho-1458683
ABSTRACT
The current COVID-19 epidemic has greatly accelerated the application of mRNA technology to our real world, and during this battle mRNA has proven it's unique advantages compared to traditional biopharmaceutical and vaccine technology. In order to overcome mRNA instability in human physiological environments, mRNA chemical modifications and nano delivery systems are two key factors for their in vivo applications. In this review, we would like to summarize the challenges for clinical translation of mRNA-based therapeutics, with an emphasis on recent advances in innovative materials and delivery strategies. The nano delivery systems include lipid delivery systems (lipid nanoparticles and liposomes), polymer complexes, micelles, cationic peptides and so on. The similarities and differences of lipid nanoparticles and liposomes are also discussed. In addition, this review also present the applications of mRNA to other areas than COVID-19 vaccine, such as infectious diseases, tumors, and cardiovascular disease, for which a variety of candidate vaccines or drugs have entered clinical trials. Furthermore, mRNA was found that it might be used to treat some genetic disease, overcome the immaturity of the immune system due to the small fetal size in utero, treat some neurological diseases that are difficult to be treated surgically, even be used in advancing the translation of iPSC technology et al. In short, mRNA has a wide range of applications, and its era has just begun.
Keywords
全文:
可用
采集:
国际数据库
资料库:
MEDLINE
主要主题:
RNA, Messenger
/
Nanoparticle Drug Delivery System
研究类型:
预后研究
话题:
疫苗
限制:
人类
语言:
英语
期刊:
Eur J Med Chem
年:
2022
类型:
文章
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