Circulating levels of calprotectin, a signature of neutrophil activation in prediction of severe respiratory failure in COVID-19 patients: a multicenter, prospective study (CalCov study).
Inflamm Res
; 71(1): 57-67, 2022 Jan.
文章
在 英语
| MEDLINE | ID: covidwho-1491056
ABSTRACT
OBJECTIVE:
Severe COVID-19 is characterized by a dysregulated immune response in which neutrophils play a critical role. Calprotectin reflects neutrophil activation and is involved in the self-amplifying thrombo-inflammatory storm in severe COVID-19. We aimed to evaluate the role of calprotectin in early prediction of severity in COVID-19 patients.METHODS:
This was a multicenter prospective observational study enrolling consecutive adult COVID-19 patients. On arrival to emergency department, blood samples were collected for laboratory tests, including serum calprotectin. The primary outcome was severe respiratory failure requiring invasive mechanical ventilation and the secondary outcome was need for Intensive Care Unit (ICU) admission.RESULTS:
Study population included 395 patients, 57 (14.4%) required invasive mechanical ventilation and 100 (25.3%) were admitted to ICU. Median serum calprotectin levels were significantly higher in intubated (3.73 mg/L vs. 2.63 mg/L; p < 0.001) and ICU patients (3.48 mg/L vs. 2.60 mg/L; p = 0.001). Calprotectin showed a significant accuracy to predict the need for invasive mechanical ventilation (ROC AUC 0.723) and ICU admission (ROC AUC 0.650). In multivariate analysis, serum calprotectin was an independent predictor of invasive mechanical ventilation (OR 1.161) and ICU admission (OR 1.068).CONCLUSION:
Serum calprotectin can be used as an early predictor of severity in COVID-19 patients.Keywords
全文:
可用
采集:
国际数据库
资料库:
MEDLINE
主要主题:
Respiration, Artificial
/
Respiratory Insufficiency
/
Neutrophil Activation
/
Leukocyte L1 Antigen Complex
/
COVID-19
/
Neutrophils
研究类型:
队列研究
/
诊断研究
/
实验研究
/
观察性研究
/
预后研究
话题:
长Covid
限制:
青少年
/
成人
/
年老的
/
女性
/
人类
/
男性
/
中年
/
年輕的成年人
语言:
英语
期刊:
Inflamm Res
期刊主题:
过敏和免疫学
/
病理学
年:
2022
类型:
文章
所属国家:
S00011-021-01516-4
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