Short Synthesis of Molnupiravir (EIDD-2801) via a Thionated Uridine Intermediate.
ACS Omega
; 6(42): 28366-28372, 2021 Oct 26.
文章
在 英语
| MEDLINE | ID: covidwho-1493021
ABSTRACT
Molnupiravir (MK-4482, EIDD-2801) is an experimental drug that has been demonstrated to be effective for the treatment of COVID-19 in human clinical trials. Herein, we report a concise synthesis of the drug via a novel thionated derivative that relies on one-pot methodologies, thus decreasing the number of purification steps required. This route provides the drug in an overall 62% yield and >99% purity and uses cheap and readily available bulk chemicals, thereby providing an affordable synthesis of the drug for cheaper and wider global accessibility.
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MEDLINE
研究类型:
预后研究
语言:
英语
期刊:
ACS Omega
年:
2021
类型:
文章
所属国家:
Acsomega.1c04550
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