Detalles de la búsqueda
1.
Anti-inflammatory effect of 3-fluorophenyl pyrimidinylimidazo[2,1-b]thiazole derivatives as p38α inhibitors.
Bioorg Chem
; 139: 106716, 2023 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-37459825
2.
Design and synthesis of novel rigid dibenzo[b,f]azepines through ring closure technique as promising anticancer candidates against leukaemia and acting as selective topoisomerase II inhibitors and DNA intercalators.
J Enzyme Inhib Med Chem
; 38(1): 2157825, 2023 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-36629421
3.
Design and synthesis of novel quinazolinone-based fibrates as PPARα agonists with antihyperlipidemic activity.
Arch Pharm (Weinheim)
; 355(3): e2100399, 2022 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-34958132
4.
Design, synthesis and anti-inflammatory activity of imidazol-5-yl pyridine derivatives as p38α/MAPK14 inhibitor.
Bioorg Med Chem
; 31: 115969, 2021 02 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33422910
5.
Anticancer profile and anti-inflammatory effect of new N-(2-((4-(1,3-diphenyl-1H-pyrazol-4-yl)pyridine sulfonamide derivatives.
Bioorg Chem
; 117: 105424, 2021 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-34678604
6.
Design, synthesis, and biological evaluation of novel imidazole derivatives possessing terminal sulphonamides as potential BRAFV600Einhibitors.
Bioorg Chem
; 106: 104508, 2021 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33280830
7.
Design, Synthesis and Anticancer Profile of New 4-(1H-benzo[d]imidazol-1-yl)pyrimidin-2-amine-Linked Sulfonamide Derivatives with V600EBRAF Inhibitory Effect.
Int J Mol Sci
; 22(19)2021 Sep 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-34638829
8.
Modification of imidazothiazole derivatives gives promising activity in B-Raf kinase enzyme inhibition; synthesis, in vitro studies and molecular docking.
Bioorg Med Chem Lett
; 30(20): 127478, 2020 10 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-32781217
9.
Inhibitory effects of triarylpyrazole derivatives on LPS-induced nitric oxide and PGE2 productions in murine RAW 264.7 macrophages.
Bioorg Med Chem Lett
; 30(4): 126884, 2020 02 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31879211
10.
Design and synthesis of novel pyrrolo[2,3-b]pyridine derivatives targeting V600EBRAF.
Bioorg Med Chem
; 28(11): 115493, 2020 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32340792
11.
Structural optimization of imidazothiazole derivatives affords a new promising series as B-Raf V600E inhibitors; synthesis, in vitro assay and in silico screening.
Bioorg Chem
; 100: 103967, 2020 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-32470760
12.
Mechanistic/mammalian target of rapamycin: Recent pathological aspects and inhibitors.
Med Res Rev
; 39(2): 631-664, 2019 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-30251347
13.
Anticancer profile of newly synthesized BRAF inhibitors possess 5-(pyrimidin-4-yl)imidazo[2,1-b]thiazole scaffold.
Bioorg Med Chem
; 27(10): 2041-2051, 2019 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30955995
14.
Thieno[2,3-d]pyrimidine as a promising scaffold in medicinal chemistry: Recent advances.
Bioorg Med Chem
; 27(7): 1159-1194, 2019 04 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30826188
15.
Design, synthesis, and anticancer activity of imidazo[2,1-b]oxazole-based RAF kinase inhibitors.
Bioorg Chem
; 93: 103349, 2019 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-31627060
16.
Design, synthesis, in vitro potent antiproliferative activity, and kinase inhibitory effects of new triarylpyrazole derivatives possessing different heterocycle terminal moieties.
J Enzyme Inhib Med Chem
; 34(1): 1534-1543, 2019 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-31452407
17.
Design, synthesis, in vitro anticancer evaluation, kinase inhibitory effects, and pharmacokinetic profile of new 1,3,4-triarylpyrazole derivatives possessing terminal sulfonamide moiety.
J Enzyme Inhib Med Chem
; 34(1): 97-109, 2019 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-30362383
18.
Synthesis of New Triarylpyrazole Derivatives Possessing Terminal Sulfonamide Moiety and Their Inhibitory Effects on PGE2 and Nitric Oxide Productions in Lipopolysaccharide-Induced RAW 264.7 Macrophages.
Molecules
; 23(10)2018 Oct 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-30301280
19.
Design, synthesis, and in vitro antiproliferative and kinase inhibitory effects of pyrimidinylpyrazole derivatives terminating with arylsulfonamido or cyclic sulfamide substituents.
J Enzyme Inhib Med Chem
; 31(sup2): 111-122, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-27255180
20.
Synthesis and broad-spectrum antiproliferative activity of diarylamides and diarylureas possessing 1,3,4-oxadiazole derivatives.
Bioorg Med Chem Lett
; 25(8): 1692-1699, 2015 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25801936