Detalles de la búsqueda
1.
Design, synthesis, apoptotic, and antiproliferative effects of 5-chloro-3- (2-methoxyvinyl)-indole-2-carboxamides and pyrido[3,4-b]indol-1-ones as potent EGFRWT/EGFRT790M inhibitors.
J Enzyme Inhib Med Chem
; 38(1): 2218602, 2023 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-37254958
2.
Design, Synthesis, and Antiproliferative Activity of New 5-Chloro-indole-2-carboxylate and Pyrrolo[3,4-b]indol-3-one Derivatives as Potent Inhibitors of EGFRT790M/BRAFV600E Pathways.
Molecules
; 28(3)2023 Jan 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-36770936
3.
New potent ciprofloxacin-uracil conjugates as DNA gyrase and topoisomerase IV inhibitors against methicillin-resistant Staphylococcus aureus.
Bioorg Med Chem
; 73: 117004, 2022 11 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36148773
4.
Optimization and SAR investigation of novel 2,3-dihydropyrazino[1,2-a]indole-1,4-dione derivatives as EGFR and BRAFV600E dual inhibitors with potent antiproliferative and antioxidant activities.
Bioorg Chem
; 120: 105616, 2022 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-35078049
5.
Design, synthesis, and biological evaluation of new series of pyrrol-2(3H)-one and pyridazin-3(2H)-one derivatives as tubulin polymerization inhibitors.
Bioorg Chem
; 107: 104522, 2021 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-33317838
6.
Novel 1,5-diaryl pyrazole-3-carboxamides as selective COX-2/sEH inhibitors with analgesic, anti-inflammatory, and lower cardiotoxicity effects.
Bioorg Chem
; 116: 105302, 2021 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-34464816
7.
Design, synthesis, and biological evaluation of novel EGFR inhibitors containing 5-chloro-3-hydroxymethyl-indole-2-carboxamide scaffold with apoptotic antiproliferative activity.
Bioorg Chem
; 112: 104960, 2021 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-34020242
8.
3,7-bis-benzylidene hydrazide ciprofloxacin derivatives as promising antiproliferative dual TOP I & TOP II isomerases inhibitors.
Bioorg Chem
; 110: 104698, 2021 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-33676043
9.
Discovery of novel oxazole-based macrocycles as anti-coronaviral agents targeting SARS-CoV-2 main protease.
Bioorg Chem
; 116: 105363, 2021 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-34555629
10.
Design and synthesis of novel 2,3-dihydropyrazino[1,2-a]indole-1,4-dione derivatives as antiproliferative EGFR and BRAFV600E dual inhibitors.
Bioorg Chem
; 104: 104260, 2020 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-32920363
11.
Discovery of novel thienoquinoline-2-carboxamide chalcone derivatives as antiproliferative EGFR tyrosine kinase inhibitors.
Bioorg Med Chem
; 27(6): 1076-1086, 2019 03 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30744932
12.
Utilization of tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidinone as a cap moiety in design of novel histone deacetylase inhibitors.
Bioorg Chem
; 91: 103127, 2019 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31374527
13.
Novel quinoline derivatives carrying nitrones/oximes nitric oxide donors: Design, synthesis, antiproliferative and caspase-3 activation activities.
Arch Pharm (Weinheim)
; 352(1): e1800270, 2019 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-30500087
14.
Novel pyrrol-2(3H)-ones and pyridazin-3(2H)-ones carrying quinoline scaffold as anti-proliferative tubulin polymerization inhibitors.
Bioorg Chem
; 80: 151-163, 2018 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-29920422
15.
Design and synthesis of pyrazolo[3,4-d]pyrimidines: Nitric oxide releasing compounds targeting hepatocellular carcinoma.
Bioorg Med Chem
; 25(12): 2956-2970, 2017 06 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28487127
16.
Design, synthesis, docking studies and biological evaluation of novel chalcone derivatives as potential histone deacetylase inhibitors.
Bioorg Chem
; 72: 32-41, 2017 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-28346873
17.
Design, Synthesis, and Biological Evaluation of Indole-2-carboxamides as Potential Multi-Target Antiproliferative Agents.
Pharmaceuticals (Basel)
; 16(7)2023 Jul 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-37513950
18.
Discovery of new 5-substituted-indole-2-carboxamides as dual epidermal growth factor receptor (EGFR)/cyclin dependent kinase-2 (CDK2) inhibitors with potent antiproliferative action.
RSC Med Chem
; 14(4): 734-744, 2023 Apr 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-37122549
19.
Synthesis and Biological Evaluation of Indole-2-Carboxamides with Potent Apoptotic Antiproliferative Activity as EGFR/CDK2 Dual Inhibitors.
Pharmaceuticals (Basel)
; 15(8)2022 Aug 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-36015154
20.
Chaxamycins A-D, bioactive ansamycins from a hyper-arid desert Streptomyces sp.
J Nat Prod
; 74(6): 1491-9, 2011 Jun 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-21553813