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1.
Development of a novel NURR1/NOT agonist from hit to lead and candidate for the potential treatment of Parkinson's disease.
Bioorg Med Chem Lett
; 29(7): 929-932, 2019 04 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30773432
2.
Preparation and optimization of new 4-(2-(indolin-1-yl)-2-oxoethyl)-2-morpholinothiazole-5-carboxylic acid and amide derivatives as potent and selective PI3Kß inhibitors.
Bioorg Med Chem Lett
; 24(6): 1506-10, 2014 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24560540
3.
Preparation and optimization of new 4-(morpholin-4-yl)-(6-oxo-1,6-dihydropyrimidin-2-yl)amide derivatives as PI3Kß inhibitors.
Bioorg Med Chem Lett
; 22(20): 6381-4, 2012 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22981333
4.
SAR439859, a Novel Selective Estrogen Receptor Degrader (SERD), Demonstrates Effective and Broad Antitumor Activity in Wild-Type and Mutant ER-Positive Breast Cancer Models.
Mol Cancer Ther
; 20(2): 250-262, 2021 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-33310762
5.
Design of potent and selective GSK3beta inhibitors with acceptable safety profile and pharmacokinetics.
Bioorg Med Chem Lett
; 20(7): 2344-9, 2010 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20189807
6.
Discovery of 6-(2,4-Dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid (SAR439859), a Potent and Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen-Receptor-Positive Breast Cancer.
J Med Chem
; 63(2): 512-528, 2020 01 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-31721572
7.
Data on synthesis, ADME and pharmacological properties and early safety pharmacology evaluation of a series of novel NURR1/NOT agonist potentially useful for the treatment of Parkinson's disease.
Data Brief
; 27: 104057, 2019 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-31687426
8.
SAR156497, an exquisitely selective inhibitor of aurora kinases.
J Med Chem
; 58(1): 362-75, 2015 Jan 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-25369539
9.
Discovery of (2S)-8-[(3R)-3-methylmorpholin-4-yl]-1-(3-methyl-2-oxobutyl)-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido[1,2-a]pyrimidin-6-one: a novel potent and selective inhibitor of Vps34 for the treatment of solid tumors.
J Med Chem
; 58(1): 376-400, 2015 Jan 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-25402320
10.
Discovery and optimization of pyrimidone indoline amide PI3Kß inhibitors for the treatment of phosphatase and tensin homologue (PTEN)-deficient cancers.
J Med Chem
; 57(3): 903-20, 2014 Feb 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-24387221
11.
In vivo testing of drug-linker stability.
Methods Mol Biol
; 1045: 101-16, 2013.
Artículo
en Inglés
| MEDLINE | ID: mdl-23913143
12.
Discovery and optimization of new benzimidazole- and benzoxazole-pyrimidone selective PI3Kß inhibitors for the treatment of phosphatase and TENsin homologue (PTEN)-deficient cancers.
J Med Chem
; 55(10): 4788-805, 2012 May 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-22524426
13.
The circadian clock components CRY1 and CRY2 are necessary to sustain sex dimorphism in mouse liver metabolism.
J Biol Chem
; 284(14): 9066-73, 2009 Apr 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-19211562
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