Detalles de la búsqueda
1.
Phthalimide-tethered isatins as novel poly(ADP-ribose) polymerase inhibitors: Design, synthesis, biological evaluations, and molecular modeling investigations.
Arch Pharm (Weinheim)
; 357(3): e2300599, 2024 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-38100160
2.
Fragment merging approach for the design of thiazole/thiazolidine clubbed pyrazoline derivatives as anti-inflammatory agents: Synthesis, biopharmacological evaluation and molecular modeling studies.
Bioorg Chem
; 139: 106724, 2023 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-37451146
3.
Development of novel anilinoquinazoline-based carboxylic acids as non-classical carbonic anhydrase IX and XII inhibitors.
J Enzyme Inhib Med Chem
; 38(1): 2191163, 2023 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-36942698
4.
Insights into the effect of elaborating coumarin-based aryl enaminones with sulfonamide or carboxylic acid functionality on carbonic anhydrase inhibitory potency and selectivity.
Bioorg Chem
; 126: 105888, 2022 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-35661530
5.
Multi-stage structure-based virtual screening approach towards identification of potential SARS-CoV-2 NSP13 helicase inhibitors.
J Enzyme Inhib Med Chem
; 37(1): 563-572, 2022 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-35012384
6.
Multi-Step In Silico Discovery of Natural Drugs against COVID-19 Targeting Main Protease.
Int J Mol Sci
; 23(13)2022 Jun 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-35805916
7.
Comparative Study of the Synthetic Approaches and Biological Activities of the Bioisosteres of 1,3,4-Oxadiazoles and 1,3,4-Thiadiazoles over the Past Decade.
Molecules
; 27(9)2022 Apr 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-35566059
8.
Synthesis, in vitro anticancer activity and in silico studies of certain isoxazole-based carboxamides, ureates, and hydrazones as potential inhibitors of VEGFR2.
Bioorg Chem
; 116: 105334, 2021 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-34534755
9.
Design and synthesis of pyrimidine-5-carbonitrile hybrids as COX-2 inhibitors: Anti-inflammatory activity, ulcerogenic liability, histopathological and docking studies.
Bioorg Chem
; 108: 104555, 2021 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-33376011
10.
Development of novel isatin-nicotinohydrazide hybrids with potent activity against susceptible/resistant Mycobacterium tuberculosis and bronchitis causing-bacteria.
J Enzyme Inhib Med Chem
; 36(1): 384-393, 2021 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-33406941
11.
Novel benzofuran-based sulphonamides as selective carbonic anhydrases IX and XII inhibitors: synthesis and in vitro biological evaluation.
J Enzyme Inhib Med Chem
; 35(1): 298-305, 2020 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-31809607
12.
Novel synthesized SLC-0111 thiazole and thiadiazole analogues: Determination of their carbonic anhydrase inhibitory activity and molecular modeling studies.
Bioorg Chem
; 87: 794-802, 2019 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-30978604
13.
Design, synthesis and in vitro antiproliferative activity of novel isatin-quinazoline hybrids.
Arch Pharm (Weinheim)
; 348(2): 144-54, 2015 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-25664631
14.
Design and synthesis of novel cytotoxic fluoroquinolone analogs through topoisomerase inhibition, cell cycle arrest, and apoptosis.
Sci Rep
; 13(1): 4144, 2023 03 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-36914702
15.
New proapoptotic chemotherapeutic agents based on the quinolone-3-carboxamide scaffold acting by VEGFR-2 inhibition.
Sci Rep
; 13(1): 11346, 2023 07 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-37443185
16.
Dual PI3K/Akt Inhibitors Bearing Coumarin-Thiazolidine Pharmacophores as Potential Apoptosis Inducers in MCF-7 Cells.
Pharmaceuticals (Basel)
; 15(4)2022 Mar 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-35455425
17.
Identification of novel piperazine-tethered phthalazines as selective CDK1 inhibitors endowed with in vitro anticancer activity toward the pancreatic cancer.
Eur J Med Chem
; 243: 114704, 2022 Dec 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-36095992
18.
New 5-Aryl-1,3,4-Thiadiazole-Based Anticancer Agents: Design, Synthesis, In Vitro Biological Evaluation and In Vivo Radioactive Tracing Studies.
Pharmaceuticals (Basel)
; 15(12)2022 Nov 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-36558927
19.
Design, synthesis and vasorelaxant evaluation of novel coumarin-pyrimidine hybrids.
Bioorg Med Chem
; 19(20): 6087-97, 2011 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21908192
20.
Novel 3-substituted coumarins as selective human carbonic anhydrase IX and XII inhibitors: Synthesis, biological and molecular dynamics analysis.
Eur J Med Chem
; 209: 112897, 2021 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33038795