Detalles de la búsqueda
1.
Unraveling the genetics of autoimmunity.
Cell
; 140(6): 791-7, 2010 Mar 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-20303870
2.
The E3 ubiquitin ligase RNF186 and RNF186 risk variants regulate innate receptor-induced outcomes.
Proc Natl Acad Sci U S A
; 118(32)2021 08 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34353900
3.
Pattern Recognition Receptor Signaling and Cytokine Networks in Microbial Defenses and Regulation of Intestinal Barriers: Implications for Inflammatory Bowel Disease.
Gastroenterology
; 162(6): 1602-1616.e6, 2022 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-35149024
4.
Pattern recognition receptor signaling in human dendritic cells is enhanced by ICOS ligand and modulated by the Crohn's disease ICOSLG risk allele.
Immunity
; 40(5): 734-46, 2014 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24837102
5.
Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells.
Nature
; 546(7660): 667-670, 2017 06 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-28636595
6.
The Tight Junction Protein ZO-1 Is Dispensable for Barrier Function but Critical for Effective Mucosal Repair.
Gastroenterology
; 161(6): 1924-1939, 2021 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-34478742
7.
Myeloid Cell-Intrinsic IRF5 Promotes T Cell Responses through Multiple Distinct Checkpoints In Vivo, and IRF5 Immune-Mediated Disease Risk Variants Modulate These Myeloid Cell Functions.
J Immunol
; 205(4): 1024-1038, 2020 08 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-32690658
8.
Disease Risk-Associated Genetic Variants in STAT1 and STAT4 Function in a Complementary Manner to Increase Pattern-Recognition Receptor-Induced Outcomes in Human Macrophages.
J Immunol
; 205(5): 1406-1418, 2020 09 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32661180
9.
Myeloid Cell Expression of LACC1 Is Required for Bacterial Clearance and Control of Intestinal Inflammation.
Gastroenterology
; 159(3): 1051-1067, 2020 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-32693188
10.
Twist1 and Twist2 Induce Human Macrophage Memory upon Chronic Innate Receptor Treatment by HDAC-Mediated Deacetylation of Cytokine Promoters.
J Immunol
; 202(11): 3297-3308, 2019 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31028123
11.
STAT3 and STAT5 Signaling Thresholds Determine Distinct Regulation for Innate Receptor-Induced Inflammatory Cytokines, and STAT3/STAT5 Disease Variants Modulate These Outcomes.
J Immunol
; 203(12): 3325-3338, 2019 12 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31732533
12.
IRF5 Is Required for Bacterial Clearance in Human M1-Polarized Macrophages, and IRF5 Immune-Mediated Disease Risk Variants Modulate This Outcome.
J Immunol
; 202(3): 920-930, 2019 02 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30593537
13.
IL23 induces IL23R recycling and amplifies innate receptor-induced signalling and cytokines in human macrophages, and the IBD-protective IL23R R381Q variant modulates these outcomes.
Gut
; 69(2): 264-273, 2020 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-31097538
14.
Prioritizing Crohn's disease genes by integrating association signals with gene expression implicates monocyte subsets.
Genes Immun
; 20(7): 577-588, 2019 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-30692607
15.
Lessons Learned From Trials Targeting Cytokine Pathways in Patients With Inflammatory Bowel Diseases.
Gastroenterology
; 152(2): 374-388.e4, 2017 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-27780712
16.
JAK2 Disease-Risk Variants Are Gain of Function and JAK Signaling Threshold Determines Innate Receptor-Induced Proinflammatory Cytokine Secretion in Macrophages.
J Immunol
; 197(9): 3695-3704, 2016 11 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27664279
17.
IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine.
Nature
; 491(7423): 259-63, 2012 Nov 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-23075849
18.
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
Nature
; 491(7422): 119-24, 2012 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23128233
19.
MTMR3 risk allele enhances innate receptor-induced signaling and cytokines by decreasing autophagy and increasing caspase-1 activation.
Proc Natl Acad Sci U S A
; 112(33): 10461-6, 2015 Aug 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-26240347
20.
A Frameshift in CSF2RB Predominant Among Ashkenazi Jews Increases Risk for Crohn's Disease and Reduces Monocyte Signaling via GM-CSF.
Gastroenterology
; 151(4): 710-723.e2, 2016 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-27377463