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1.
Discovery of 1,8-naphthyridin-2-one derivative as a potent and selective sphingomyelin synthase 2 inhibitor.
Bioorg Med Chem
; 28(7): 115376, 2020 04 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32088125
2.
Pharmacological characterization of synthetic serine palmitoyltransferase inhibitors by biochemical and cellular analyses.
Biochem Biophys Res Commun
; 497(4): 1171-1176, 2018 03 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-28042036
3.
Discovery of novel serine palmitoyltransferase inhibitors as cancer therapeutic agents.
Bioorg Med Chem
; 26(9): 2452-2465, 2018 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29669694
4.
Discovery of a novel prolyl-tRNA synthetase inhibitor and elucidation of its binding mode to the ATP site in complex with l-proline.
Biochem Biophys Res Commun
; 488(2): 393-399, 2017 06 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-28501621
5.
Antitumor activity of a novel and orally available inhibitor of serine palmitoyltransferase.
Biochem Biophys Res Commun
; 484(3): 493-500, 2017 03 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-28108287
6.
Prolyl-tRNA synthetase inhibition promotes cell death in SK-MEL-2 cells through GCN2-ATF4 pathway activation.
Biochem Biophys Res Commun
; 488(4): 648-654, 2017 07 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-28087278
7.
Optimization of a novel series of N-phenylindoline-5-sulfonamide-based acyl CoA:monoacylglycerol acyltransferase-2 inhibitors: Mitigation of CYP3A4 time-dependent inhibition and phototoxic liabilities.
Bioorg Med Chem
; 23(15): 4544-4560, 2015 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26100443
8.
Estimation of the total population moving into and out of the 20 km evacuation zone during the Fukushima NPP accident as calculated using "Auto-GPS" mobile phone data.
Proc Jpn Acad Ser B Phys Biol Sci
; 89(5): 196-9, 2013.
Artículo
en Inglés
| MEDLINE | ID: mdl-23666090
9.
Anti-human-TIGIT agonistic antibody ameliorates autoimmune diseases by inhibiting Tfh and Tph cells and enhancing Treg cells.
Commun Biol
; 6(1): 500, 2023 05 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-37161050
10.
Inhibition of MGAT2 modulates fat-induced gut peptide release and fat intake in normal mice and ameliorates obesity and diabetes in ob/ob mice fed on a high-fat diet.
FEBS Open Bio
; 10(3): 316-326, 2020 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-31837122
11.
Discovery of Human Intestinal MGAT Inhibitors Using High-Throughput Mass Spectrometry.
SLAS Discov
; 22(4): 360-365, 2017 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-28328319
12.
Using a biologically annotated library to analyze the anticancer mechanism of serine palmitoyl transferase (SPT) inhibitors.
FEBS Open Bio
; 7(4): 495-503, 2017 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-28396835
13.
Discovery and pharmacological characterization of a new class of prolyl-tRNA synthetase inhibitor for anti-fibrosis therapy.
PLoS One
; 12(10): e0186587, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-29065190
14.
Discovery and characterization of selective human sphingomyelin synthase 2 inhibitors.
Eur J Med Chem
; 136: 283-293, 2017 Aug 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-28505533
15.
Identification of cytidine-5-triphosphate synthase1-selective inhibitory peptide from random peptide library displayed on T7 phage.
Peptides
; 94: 56-63, 2017 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-28676225
16.
Pharmacological characterization of a series of aryl-sulfonamide derivatives that potently and selectively inhibit monoacylglycerol acyltransferase 2.
Eur J Pharmacol
; 791: 569-577, 2016 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27658346
17.
Pharmacological Inhibition of Monoacylglycerol O-Acyltransferase 2 Improves Hyperlipidemia, Obesity, and Diabetes by Change in Intestinal Fat Utilization.
PLoS One
; 11(3): e0150976, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-26938273
18.
Enhancement of ligand-dependent vitamin D receptor transactivation by the cardiotonic steroid bufalin.
Biochem Pharmacol
; 70(10): 1479-86, 2005 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-16183038
19.
Structural determinants for vitamin D receptor response to endocrine and xenobiotic signals.
Mol Endocrinol
; 18(1): 43-52, 2004 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-14525957
20.
Discovery of a Novel Series of N-Phenylindoline-5-sulfonamide Derivatives as Potent, Selective, and Orally Bioavailable Acyl CoA:Monoacylglycerol Acyltransferase-2 Inhibitors.
J Med Chem
; 58(9): 3892-909, 2015 May 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-25897973