Detalles de la búsqueda
1.
High-resolution structure of the human GPR40 receptor bound to allosteric agonist TAK-875.
Nature
; 513(7516): 124-7, 2014 Sep 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-25043059
2.
Target Engagement of a Phosphodiesterase 2A Inhibitor Affecting Long-Term Memory in the Rat.
J Pharmacol Exp Ther
; 370(3): 399-407, 2019 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-31253692
3.
Method for rapid optimization of recombinant GPCR protein expression and stability using virus-like particles.
Protein Expr Purif
; 133: 41-49, 2017 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-28263854
4.
Structural analysis of the mechanism of inhibition and allosteric activation of the kinase domain of HER2 protein.
J Biol Chem
; 286(21): 18756-65, 2011 May 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-21454582
5.
Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors: 3. Evaluation of 5-amino-linked thiazolo[5,4-d]pyrimidine and thiazolo[5,4-b]pyridine derivatives.
Bioorg Med Chem
; 20(18): 5600-15, 2012 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22883026
6.
Optimization of Recombinant GPCR Proteins for Biophysical and Structural Studies Using Virus-like Particles.
Methods Mol Biol
; 2507: 327-336, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-35773590
7.
Discovery of potent, selective, and orally bioavailable quinoline-based dipeptidyl peptidase IV inhibitors targeting Lys554.
Bioorg Med Chem
; 19(15): 4482-98, 2011 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21741847
8.
Identification of 3-aminomethyl-1,2-dihydro-4-phenyl-1-isoquinolones: a new class of potent, selective, and orally active non-peptide dipeptidyl peptidase IV inhibitors that form a unique interaction with Lys554.
Bioorg Med Chem
; 19(16): 4953-70, 2011 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21764322
9.
Design and synthesis of 3-pyridylacetamide derivatives as dipeptidyl peptidase IV (DPP-4) inhibitors targeting a bidentate interaction with Arg125.
Bioorg Med Chem
; 19(1): 172-85, 2011 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21163664
10.
Plasminogen activator inhibitor-1 detaches cells from extracellular matrices by inactivating integrins.
J Cell Biol
; 160(5): 781-91, 2003 Mar 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-12615913
11.
Mathematical and Structural Characterization of Strong Nonadditive Structure-Activity Relationship Caused by Protein Conformational Changes.
J Med Chem
; 61(17): 7754-7766, 2018 09 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-30070482
12.
Dataset on Galanin Receptor 3 mutants that improve recombinant receptor expression and stability in an agonist and antagonist bound form.
Data Brief
; 12: 603-607, 2017 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-28540352
13.
Design and Synthesis of Novel and Selective Phosphodiesterase 2 (PDE2a) Inhibitors for the Treatment of Memory Disorders.
J Med Chem
; 60(5): 2037-2051, 2017 03 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-28165743
14.
Discovery of Selective Phosphodiesterase 1 Inhibitors with Memory Enhancing Properties.
J Med Chem
; 60(8): 3472-3483, 2017 04 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-28406621
15.
Outcome of the First wwPDB/CCDC/D3R Ligand Validation Workshop.
Structure
; 24(4): 502-508, 2016 Apr 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-27050687
16.
N-linked glycosylation of dipeptidyl peptidase IV (CD26): effects on enzyme activity, homodimer formation, and adenosine deaminase binding.
Protein Sci
; 13(1): 145-54, 2004 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-14691230
17.
Crystal structure of human dipeptidyl peptidase IV in complex with a decapeptide reveals details on substrate specificity and tetrahedral intermediate formation.
Protein Sci
; 13(2): 412-21, 2004 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-14718659
18.
Discovery of a selective kinase inhibitor (TAK-632) targeting pan-RAF inhibition: design, synthesis, and biological evaluation of C-7-substituted 1,3-benzothiazole derivatives.
J Med Chem
; 56(16): 6478-94, 2013 Aug 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-23906342
19.
Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors. 1. Exploration of [5,6]-fused bicyclic scaffolds.
J Med Chem
; 55(7): 3452-78, 2012 Apr 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-22376051
20.
Design and synthesis of pyrimidinone and pyrimidinedione inhibitors of dipeptidyl peptidase IV.
J Med Chem
; 54(2): 510-24, 2011 Jan 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-21186796