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Discovery of 1'-(1-phenylcyclopropane-carbonyl)-3H-spiro[isobenzofuran-1,3'-pyrrolidin]-3-one as a novel steroid mimetic scaffold for the potent and tissue-specific inhibition of 11ß-HSD1 using a scaffold-hopping approach.
Bioorg Med Chem Lett
; 69: 128782, 2022 08 01.
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en Inglés
| MEDLINE | ID: mdl-35537608
2.
Discovery of a potent, selective, and orally active human epidermal growth factor receptor-2 sheddase inhibitor for the treatment of cancer.
J Med Chem
; 50(4): 603-6, 2007 Feb 22.
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en Inglés
| MEDLINE | ID: mdl-17256836
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Identification of ADAM10 as a major source of HER2 ectodomain sheddase activity in HER2 overexpressing breast cancer cells.
Cancer Biol Ther
; 5(6): 657-64, 2006 Jun.
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en Inglés
| MEDLINE | ID: mdl-16627989
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