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1.
Initial Pharmacological Characterization of a Major Hydroxy Metabolite of PF-5190457: Inverse Agonist Activity of PF-6870961 at the Ghrelin Receptor.
J Pharmacol Exp Ther
; 386(2): 117-128, 2023 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-36631279
2.
A deeper insight into how GABA-B receptor agonism via baclofen may affect alcohol seeking and consumption: lessons learned from a human laboratory investigation.
Mol Psychiatry
; 26(2): 545-555, 2021 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-30382188
3.
The glucagon-like peptide-1 system is modulated by acute and chronic alcohol exposure: Findings from human laboratory experiments and a post-mortem brain study.
Addict Biol
; 27(5): e13211, 2022 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-36001436
4.
A closer look at alcohol-induced changes in the ghrelin system: novel insights from preclinical and clinical data.
Addict Biol
; 27(1): e13033, 2022 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33908131
5.
Neuroendocrine Response to Exogenous Ghrelin Administration, Combined With Alcohol, in Heavy-Drinking Individuals: Findings From a Randomized, Double-Blind, Placebo-Controlled Human Laboratory Study.
Int J Neuropsychopharmacol
; 24(6): 464-476, 2021 07 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-33560411
6.
The novel ghrelin receptor inverse agonist PF-5190457 administered with alcohol: preclinical safety experiments and a phase 1b human laboratory study.
Mol Psychiatry
; 25(2): 461-475, 2020 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-29728704
7.
Treprostinil, a prostacyclin analog, ameliorates renal ischemia-reperfusion injury: preclinical studies in a rat model of acute kidney injury.
Nephrol Dial Transplant
; 36(2): 257-266, 2021 01 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-33156922
8.
Synthesis of PF-6870961, a major hydroxy metabolite of the novel ghrelin receptor inverse agonist PF-5190457.
Bioorg Med Chem
; 50: 116465, 2021 11 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34662828
9.
Anti-neuroinflammatory effects of a food-grade phenolic-enriched maple syrup extract in a mouse model of Alzheimer's disease.
Nutr Neurosci
; 24(9): 710-719, 2021 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-31583972
10.
Development of a Physiologically Based Pharmacokinetic Model for Prediction of Ethanol Concentration-Time Profile in Different Organs.
Alcohol Alcohol
; 56(4): 401-414, 2021 Jun 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-33316031
11.
Perfluorooctanesulfonic acid (PFOS) administration shifts the hepatic proteome and augments dietary outcomes related to hepatic steatosis in mice.
Toxicol Appl Pharmacol
; 408: 115250, 2020 12 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32979393
12.
Most Influential Physicochemical and In Vitro Assay Descriptors for Hepatotoxicity and Nephrotoxicity Prediction.
Chem Res Toxicol
; 33(7): 1780-1790, 2020 07 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-32338883
13.
Role of Molybdenum-Containing Enzymes in the Biotransformation of the Novel Ghrelin Receptor Inverse Agonist PF-5190457: A Reverse Translational Bed-to-Bench Approach.
Drug Metab Dispos
; 47(8): 874-882, 2019 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-31182423
14.
Nonalcoholic Fatty Liver Disease and Diabetes Are Associated with Decreased CYP3A4 Protein Expression and Activity in Human Liver.
Mol Pharm
; 15(7): 2621-2632, 2018 07 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-29792708
15.
Identifying and Characterizing Subpopulations of Heavy Alcohol Drinkers Via a Sucrose Preference Test: A Sweet Road to a Better Phenotypic Characterization?
Alcohol Alcohol
; 53(5): 560-569, 2018 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30016385
16.
Multiplex and Label-Free Relative Quantification Approach for Studying Protein Abundance of Drug Metabolizing Enzymes in Human Liver Microsomes Using SWATH-MS.
J Proteome Res
; 16(11): 4134-4143, 2017 11 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-28944677
17.
Non-alcoholic fatty liver disease (NAFLD) - pathogenesis, classification, and effect on drug metabolizing enzymes and transporters.
Drug Metab Rev
; 49(2): 197-211, 2017 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-28303724
18.
Interleukin-2 receptor antagonist therapy leads to increased tacrolimus levels after kidney transplantation.
Ther Drug Monit
; 37(2): 206-13, 2015 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-25162212
19.
Development and validation of an UPLC-MS/MS assay for quantitative analysis of the ghrelin receptor inverse agonist PF-5190457 in human or rat plasma and rat brain.
Anal Bioanal Chem
; 407(19): 5603-13, 2015 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-25943263
20.
Pharmacokinetics of total and unbound prednisone and prednisolone in stable kidney transplant recipients with diabetes mellitus.
Ther Drug Monit
; 36(4): 448-55, 2014 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-24452065