Detalles de la búsqueda
1.
A phase I/II study of KW-2478, an Hsp90 inhibitor, in combination with bortezomib in patients with relapsed/refractory multiple myeloma.
Br J Cancer
; 117(9): 1295-1302, 2017 Oct 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-28873084
2.
Phase I study of KW-2478, a novel Hsp90 inhibitor, in patients with B-cell malignancies.
Br J Cancer
; 114(1): 7-13, 2016 Jan 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-26695442
3.
A randomized, double-blind, placebo-controlled, phase III trial of erlotinib with or without a c-Met inhibitor tivantinib (ARQ 197) in Asian patients with previously treated stage IIIB/IV nonsquamous nonsmall-cell lung cancer harboring wild-type epidermal growth factor receptor (ATTENTION study).
Ann Oncol
; 26(10): 2066-72, 2015 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-26153496
4.
CYP2C19 genotype-based phase I studies of a c-Met inhibitor tivantinib in combination with erlotinib, in advanced/metastatic non-small cell lung cancer.
Br J Cancer
; 109(11): 2803-9, 2013 Nov 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-24169346
5.
The effect of CYP2C19 polymorphism on the safety, tolerability, and pharmacokinetics of tivantinib (ARQ 197): results from a phase I trial in advanced solid tumors.
Ann Oncol
; 24(6): 1653-9, 2013 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-23413279
6.
Analysis of receptors, cell surface antigens, and proteins in human melanoma cell lines resistant to human recombinant beta- or gamma-interferon.
Cancer Res
; 46(12 Pt 1): 6211-6, 1986 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-2430691
7.
Antitumor activity of UCN-01, a selective inhibitor of protein kinase C, in murine and human tumor models.
Cancer Res
; 51(18): 4888-92, 1991 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-1893379
8.
G1 phase accumulation induced by UCN-01 is associated with dephosphorylation of Rb and CDK2 proteins as well as induction of CDK inhibitor p21/Cip1/WAF1/Sdi1 in p53-mutated human epidermoid carcinoma A431 cells.
Cancer Res
; 57(8): 1495-501, 1997 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-9108451
9.
Decrease in susceptibility toward induction of apoptosis and alteration in G1 checkpoint function as determinants of resistance of human lung cancer cells against the antisignaling drug UCN-01 (7-Hydroxystaurosporine).
Cancer Res
; 59(17): 4406-12, 1999 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-10485490
10.
KF25706, a novel oxime derivative of radicicol, exhibits in vivo antitumor activity via selective depletion of Hsp90 binding signaling molecules.
Cancer Res
; 59(12): 2931-8, 1999 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-10383157
11.
Unpredicted clinical pharmacology of UCN-01 caused by specific binding to human alpha1-acid glycoprotein.
Cancer Res
; 58(15): 3248-53, 1998 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-9699650
12.
Destabilization of steroid receptors by heat shock protein 90-binding drugs: a ligand-independent approach to hormonal therapy of breast cancer.
Clin Cancer Res
; 7(7): 2076-84, 2001 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-11448926
13.
Induction of a heat shock factor 1-dependent stress response alters the cytotoxic activity of hsp90-binding agents.
Clin Cancer Res
; 6(8): 3312-8, 2000 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-10955818
14.
Interaction of radicicol with members of the heat shock protein 90 family of molecular chaperones.
Mol Endocrinol
; 13(9): 1435-48, 1999 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-10478836
15.
In vitro and in vivo effects of KT6352, a derivative of indolocarbazole compounds, on murine megakaryocytopoiesis.
Exp Hematol
; 26(13): 1195-201, 1998 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-9845374
16.
6H-pyrazolo[4,5,1-de]acridin-6-ones as a novel class of antitumor agents. Synthesis and biological activity.
J Med Chem
; 37(7): 1028-32, 1994 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-8151613
17.
Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin.
Cell Stress Chaperones
; 3(2): 100-8, 1998 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-9672245
18.
Enhancement of antitumor activity of mitomycin C in vitro and in vivo by UCN-01, a selective inhibitor of protein kinase C.
Cancer Chemother Pharmacol
; 32(3): 183-9, 1993.
Artículo
en Inglés
| MEDLINE | ID: mdl-8500222
19.
Effect of UCN-01, a selective inhibitor of protein kinase C, on the cell-cycle distribution of human epidermoid carcinoma, A431 cells.
Cancer Chemother Pharmacol
; 33(4): 273-80, 1994.
Artículo
en Inglés
| MEDLINE | ID: mdl-7506638
20.
Antitumor activity of 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) adenine, a novel deoxyadenosine analog, against human colon tumor xenografts by oral administration.
Cancer Chemother Pharmacol
; 43(3): 233-40, 1999.
Artículo
en Inglés
| MEDLINE | ID: mdl-9923554