Detalles de la búsqueda
1.
Scaffold oriented synthesis. Part 4: design, synthesis and biological evaluation of novel 5-substituted indazoles as potent and selective kinase inhibitors employing heterocycle forming and multicomponent reactions.
Bioorg Med Chem Lett
; 21(5): 1480-3, 2011 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21288717
2.
Scaffold oriented synthesis. Part 3: design, synthesis and biological evaluation of novel 5-substituted indazoles as potent and selective kinase inhibitors employing [2+3] cycloadditions.
Bioorg Med Chem Lett
; 21(5): 1476-9, 2011 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21282054
3.
Small molecule library synthesis using segmented flow.
Molecules
; 16(11): 9161-77, 2011 Nov 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-22048699
4.
Isocyanide-based multicomponent reactions in drug discovery.
Curr Opin Chem Biol
; 12(3): 324-31, 2008 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-18312861
5.
Scaffold oriented synthesis. Part 2: Design, synthesis and biological evaluation of pyrimido-diazepines as receptor tyrosine kinase inhibitors.
Bioorg Med Chem Lett
; 18(8): 2691-5, 2008 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18362070
6.
Discovery of Novel Aminotetralines and Aminochromanes as Selective and Competitive Glycine Transporter 1 (GlyT1) Inhibitors.
J Med Chem
; 61(17): 7503-7524, 2018 09 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-30080045
7.
De Novo Design, Synthesis, and Biological Evaluation of 3,4-Disubstituted Pyrrolidine Sulfonamides as Potent and Selective Glycine Transporter 1 Competitive Inhibitors.
J Med Chem
; 61(17): 7486-7502, 2018 09 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-29969029
8.
Topography-biased compound library design: the shape of things to come?
Drug Discov Today
; 12(21-22): 948-52, 2007 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-17993413
9.
1,4-Dihydroindeno[1,2-c]pyrazoles with acetylenic side chains as novel and potent multitargeted receptor tyrosine kinase inhibitors with low affinity for the hERG ion channel.
J Med Chem
; 50(9): 2011-29, 2007 May 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-17425296
10.
Synthesis of novel and uniquely shaped 3-azabicyclo[4.2.0]octan-4-one derivatives by sequential Ugi/[2+2] ene-enone photocycloadditions.
Org Lett
; 9(7): 1299-302, 2007 Mar 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-17323962
11.
Concise construction of novel bridged bicyclic lactams by sequenced Ugi/RCM/Heck reactions.
Org Lett
; 9(24): 5119-22, 2007 Nov 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-17973488
12.
The identification of new protein kinase inhibitors as targets in modern drug discovery.
IDrugs
; 9(7): 481-7, 2006 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-16821161
13.
Design, synthesis and bioactions of novel stable mimetics of lipoxins and aspirin-triggered lipoxins.
Prostaglandins Leukot Essent Fatty Acids
; 73(3-4): 301-21, 2005.
Artículo
en Inglés
| MEDLINE | ID: mdl-16098719
14.
When analoging is not enough: scaffold discovery in medicinal chemistry.
Expert Opin Drug Discov
; 5(2): 123-34, 2010 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-22822912
15.
Kinase-targeted libraries: the design and synthesis of novel, potent, and selective kinase inhibitors.
Drug Discov Today
; 14(5-6): 291-7, 2009 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-19121409
16.
Synthesis and biological evaluation of 5-substituted 1,4-dihydroindeno[1,2-c]pyrazoles as multitargeted receptor tyrosine kinase inhibitors.
Bioorg Med Chem Lett
; 17(11): 3136-40, 2007 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17391959
17.
The use of three-dimensional shape and electrostatic similarity searching in the identification of a melanin-concentrating hormone receptor 1 antagonist.
Chem Biol Drug Des
; 67(2): 174-6, 2006 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-16492165
18.
Scaffold oriented synthesis. Part 1: Design, preparation, and biological evaluation of thienopyrazoles as kinase inhibitors.
Bioorg Med Chem Lett
; 16(1): 96-9, 2006 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16216502
19.
1,4-Dihydroindeno[1,2-c]pyrazoles as novel multitargeted receptor tyrosine kinase inhibitors.
Bioorg Med Chem Lett
; 16(16): 4266-71, 2006 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-16759855
20.
Hit-to-lead optimization of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of KDR kinase inhibitors.
Bioorg Med Chem Lett
; 16(16): 4371-5, 2006 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-16750628