Detalles de la búsqueda
1.
Design and Synthesis of 56 Shape-Diverse 3D Fragments.
Chemistry
; 26(41): 8969-8975, 2020 Jul 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-32315100
2.
Exploration of piperidine 3D fragment chemical space: synthesis and 3D shape analysis of fragments derived from 20 regio- and diastereoisomers of methyl substituted pipecolinates.
RSC Med Chem
; 13(12): 1614-1620, 2022 Dec 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-36545433
3.
Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor.
ACS Med Chem Lett
; 13(10): 1591-1597, 2022 Oct 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-36262388
4.
Estimating peak work rate during incremental cycle ergometry from the 6-minute walk distance: differences between reference equations.
Respiration
; 81(2): 124-8, 2011.
Artículo
en Inglés
| MEDLINE | ID: mdl-20357426
5.
Fragment-Guided Discovery of Pyrazole Carboxylic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2 Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction.
J Med Chem
; 64(21): 15949-15972, 2021 11 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-34705450
6.
ASTX029, a Novel Dual-mechanism ERK Inhibitor, Modulates Both the Phosphorylation and Catalytic Activity of ERK.
Mol Cancer Ther
; 20(10): 1757-1768, 2021 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34330842
7.
Discovery of ASTX029, A Clinical Candidate Which Modulates the Phosphorylation and Catalytic Activity of ERK1/2.
J Med Chem
; 64(16): 12286-12303, 2021 08 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-34387469
8.
Maintaining benefits following pulmonary rehabilitation: a randomised controlled trial.
Eur Respir J
; 35(3): 571-7, 2010 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-19643944
9.
High- and low-level pressure support during walking in people with severe kyphoscoliosis.
Eur Respir J
; 36(2): 370-8, 2010 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-20075055
10.
Interventions to promote physical activity in people with cystic fibrosis.
Paediatr Respir Rev
; 15(3): 237-9, 2014 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-24962457
11.
Structure-Activity and Structure-Conformation Relationships of Aryl Propionic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1/Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1/NRF2) Protein-Protein Interaction.
J Med Chem
; 62(9): 4683-4702, 2019 05 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-30973731
12.
Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2.
J Med Chem
; 61(11): 4978-4992, 2018 06 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-29775310
13.
Effect of non-invasive ventilation on the measurement of ventilatory and metabolic variables.
Respir Physiol Neurobiol
; 228: 76-82, 2016 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-26932772
14.
Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery.
J Med Chem
; 59(8): 3991-4006, 2016 04 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-27031670
15.
Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2).
J Med Chem
; 59(23): 10738-10749, 2016 12 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27933945
16.
Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening.
J Med Chem
; 59(11): 5356-67, 2016 06 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-27167608
17.
Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP.
J Med Chem
; 58(16): 6574-88, 2015 Aug 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-26218264
18.
Comparison of two methods of assessing physical performance in patients with chronic airway obstruction.
Phys Ther
; 61(9): 1278-80, 1981 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-7267713
19.
Evaluation of exercise training in patients with chronic airway obstruction.
Phys Ther
; 61(9): 1273-7, 1981 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-7267712
20.
The effect of a comprehensive, intensive inpatient treatment program on lung function and exercise capacity in patients with cystic fibrosis.
Phys Ther
; 74(6): 583-91; discussion 591-3, 1994 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-8197244