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1.
Human retroviral antisense mRNAs are retained in the nuclei of infected cells for viral persistence.
Proc Natl Acad Sci U S A
; 118(17)2021 04 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-33875584
2.
Evaluation of darunavir-derived HIV-1 protease inhibitors incorporating P2' amide-derivatives: Synthesis, biological evaluation and structural studies.
Bioorg Med Chem Lett
; 83: 129168, 2023 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36738797
3.
Fluorine Modifications Contribute to Potent Antiviral Activity against Highly Drug-Resistant HIV-1 and Favorable Blood-Brain Barrier Penetration Property of Novel Central Nervous System-Targeting HIV-1 Protease Inhibitors In Vitro.
Antimicrob Agents Chemother
; 66(2): e0171521, 2022 02 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34978889
4.
A Small Molecule, ACAi-028, with Anti-HIV-1 Activity Targets a Novel Hydrophobic Pocket on HIV-1 Capsid.
Antimicrob Agents Chemother
; 65(10): e0103921, 2021 09 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-34228546
5.
A Conformational Escape Reaction of HIV-1 against an Allosteric Integrase Inhibitor.
J Virol
; 94(19)2020 09 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-32611758
6.
Filifactor alocis brain abscess identified by 16S ribosomal RNA gene sequencing: A case report.
J Infect Chemother
; 26(2): 305-307, 2020 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-31711830
7.
Novel p97/VCP inhibitor induces endoplasmic reticulum stress and apoptosis in both bortezomib-sensitive and -resistant multiple myeloma cells.
Cancer Sci
; 110(10): 3275-3287, 2019 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-31368616
8.
Novel Protease Inhibitors Containing C-5-Modified bis-Tetrahydrofuranylurethane and Aminobenzothiazole as P2 and P2' Ligands That Exert Potent Antiviral Activity against Highly Multidrug-Resistant HIV-1 with a High Genetic Barrier against the Emergence of Drug Resistance.
Antimicrob Agents Chemother
; 63(8)2019 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-31085520
9.
Novel Central Nervous System (CNS)-Targeting Protease Inhibitors for Drug-Resistant HIV Infection and HIV-Associated CNS Complications.
Antimicrob Agents Chemother
; 63(7)2019 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-31061155
10.
Case of endobronchial metastasis from breast cancer accompanied with Cunninghamella bertholletiae tracheobronchial mycetoma.
J Infect Chemother
; 25(12): 1065-1069, 2019 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-31227382
11.
Third-Dose BNT162b2 Vaccination Elicits Markedly High-Level SARS-CoV-2-Neutralizing Antibodies in Vaccinees Who Responded Poorly to a Second Dose in Japan.
J Infect Dis
; 226(11): 2038-2039, 2022 11 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-35580786
12.
Restoration of Neutralization Activity Against Omicron BA.2 and BA.5 in Older Adults and Individuals With Risk Factors Following the Fourth Dose of Severe Acute Respiratory Syndrome Coronavirus 2 BNT162b2 Vaccine.
J Infect Dis
; 227(1): 161-163, 2022 12 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-36134611
13.
Design, synthesis, X-ray studies, and biological evaluation of novel macrocyclic HIV-1 protease inhibitors involving the P1'-P2' ligands.
Bioorg Med Chem Lett
; 27(21): 4925-4931, 2017 11 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28958624
14.
Design of novel HIV-1 protease inhibitors incorporating isophthalamide-derived P2-P3 ligands: Synthesis, biological evaluation and X-ray structural studies of inhibitor-HIV-1 protease complex.
Bioorg Med Chem
; 25(19): 5114-5127, 2017 10 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28434781
15.
A Modified P1 Moiety Enhances In Vitro Antiviral Activity against Various Multidrug-Resistant HIV-1 Variants and In Vitro Central Nervous System Penetration Properties of a Novel Nonpeptidic Protease Inhibitor, GRL-10413.
Antimicrob Agents Chemother
; 60(12): 7046-7059, 2016 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-27620483
16.
Immunomodulatory drugs act as inhibitors of DNA methyltransferases and induce PU.1 up-regulation in myeloma cells.
Biochem Biophys Res Commun
; 469(2): 236-42, 2016 Jan 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-26657848
17.
4'-modified nucleoside analogs: potent inhibitors active against entecavir-resistant hepatitis B virus.
Hepatology
; 62(4): 1024-36, 2015 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-26122273
18.
Diastereoselective Synthesis of 6â³-(Z)- and 6â³-(E)-Fluoro Analogues of Anti-hepatitis B Virus Agent Entecavir and Its Evaluation of the Activity and Toxicity Profile of the Diastereomers.
J Org Chem
; 81(7): 2827-36, 2016 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27009432
19.
A novel tricyclic ligand-containing nonpeptidic HIV-1 protease inhibitor, GRL-0739, effectively inhibits the replication of multidrug-resistant HIV-1 variants and has a desirable central nervous system penetration property in vitro.
Antimicrob Agents Chemother
; 59(5): 2625-35, 2015 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-25691652
20.
Structure-based design, synthesis, X-ray studies, and biological evaluation of novel HIV-1 protease inhibitors containing isophthalamide-derived P2-ligands.
Bioorg Med Chem Lett
; 25(21): 4903-4909, 2015 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26096678