Detalles de la búsqueda
1.
Discovery and development of ASK1 inhibitors.
Prog Med Chem
; 59: 101-179, 2020.
Artículo
en Inglés
| MEDLINE | ID: mdl-32362327
2.
Stereocontrolled synthesis of 5-azaspiro[2.3]hexane derivatives as conformationally "frozen" analogues of L-glutamic acid.
Beilstein J Org Chem
; 10: 1114-20, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-24991261
3.
Discovery of GLPG3667, a Selective ATP Competitive Tyrosine Kinase 2 Inhibitor for the Treatment of Autoimmune Diseases.
J Med Chem
; 67(11): 8545-8568, 2024 Jun 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-38805213
4.
Discovery of Clinical Candidate GLPG3970: A Potent and Selective Dual SIK2/SIK3 Inhibitor for the Treatment of Autoimmune and Inflammatory Diseases.
J Med Chem
; 67(7): 5233-5258, 2024 Apr 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-38552030
5.
Optimization of Selectivity and Pharmacokinetic Properties of Salt-Inducible Kinase Inhibitors that Led to the Discovery of Pan-SIK Inhibitor GLPG3312.
J Med Chem
; 67(1): 380-401, 2024 Jan 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-38147525
6.
Synthesis of 1,2,4-triazines and the triazinoisoquinolinedione DEF ring system of noelaquinone.
Org Biomol Chem
; 10(30): 5811-4, 2012 Aug 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-22473572
7.
Safety, Pharmacokinetics, and Pharmacodynamics of the ADAMTS-5 Inhibitor GLPG1972/S201086 in Healthy Volunteers and Participants With Osteoarthritis of the Knee or Hip.
Clin Pharmacol Drug Dev
; 11(1): 112-122, 2022 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34859612
8.
Discovery of GLPG1972/S201086, a Potent, Selective, and Orally Bioavailable ADAMTS-5 Inhibitor for the Treatment of Osteoarthritis.
J Med Chem
; 64(6): 2937-2952, 2021 03 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-33719441
9.
Functional magnetic resonance imaging reveals different neural substrates for the effects of orexin-1 and orexin-2 receptor antagonists.
PLoS One
; 6(1): e16406, 2011 Jan 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-21307957
10.
Synthesis of 4-aryl-1H-1,2,3-triazoles through TBAF-catalyzed [3 + 2] cycloaddition of 2-aryl-1-nitroethenes with TMSN3 under solvent-free conditions.
J Org Chem
; 70(16): 6526-9, 2005 Aug 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-16050724
11.
Uncatalyzed [4 + 2] cycloadditions of 3-nitrocoumarins with vinyl ethers in solventless conditions. A new entry to chromene derivatives.
J Org Chem
; 67(21): 7238-43, 2002 Oct 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-12375949
12.
3-nitrocoumarins as dienophiles in the Diels-Alder reaction in water. An approach to the synthesis of nitrotetrahydrobenzo[c]chromenones and dihydrodibenzo[b,d]furans.
J Org Chem
; 68(24): 9263-8, 2003 Nov 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-14629145
13.
TBAF-catalyzed synthesis of 5-substituted 1H-tetrazoles under solventless conditions.
J Org Chem
; 69(8): 2896-8, 2004 Apr 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-15074950
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