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1.
The Disposition and Metabolism of Bempedoic Acid, a Potent Inhibitor of ATP Citrate Lyase, in Healthy Human Subjects.
Drug Metab Dispos
; 51(5): 599-609, 2023 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-36878717
2.
Population pharmacokinetic and pharmacokinetic-pharmacodynamic modeling of bempedoic acid and low-density lipoprotein cholesterol in healthy subjects and patients with dyslipidemia.
J Pharmacokinet Pharmacodyn
; 50(5): 351-364, 2023 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-37243877
3.
A Phase 1 study evaluating AMG 337 in Asian patients with advanced solid tumors.
Jpn J Clin Oncol
; 47(8): 772-776, 2017 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28582510
4.
Intestinal and hepatic first-pass extraction of the 11ß-HSD1 inhibitor AMG 221 in rats with chronic vascular catheters.
Xenobiotica
; 44(3): 264-9, 2014 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-23517558
5.
Phase 1, Single- and Multiple-Ascending-Dose, Food-Effect, and East Asian Subject Studies to Assess the Pharmacokinetics, Safety, and Tolerability of Bempedoic Acid, a Selective Inhibitor of Adenosine Triphosphate Citrate Lyase.
Clin Pharmacol Drug Dev
; 12(10): 1022-1035, 2023 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-37477389
6.
Physiologically Based Pharmacokinetic Model Development and Verification for Bioequivalence Testing of Bempedoic Acid Oral Suspension and Reference Tablet Formulation.
Pharmaceutics
; 15(5)2023 May 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-37242718
7.
Predicting the drug interaction potential of AMG 853, a dual antagonist of the D-prostanoid and chemoattractant receptor-homologous molecule expressed on T helper 2 cells receptors.
Drug Metab Dispos
; 40(12): 2239-49, 2012 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-22930276
8.
Pharmacokinetics of bempedoic acid in patients with renal impairment.
Clin Transl Sci
; 15(3): 789-798, 2022 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-34800002
9.
Pharmacodynamic effect of bempedoic acid and statin combinations: predictions from a dose-response model.
Eur Heart J Cardiovasc Pharmacother
; 8(6): 578-586, 2022 Sep 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-34448822
10.
Absence of effect of steady state bempedoic acid on cardiac repolarization: Results of a thorough QT/QTc study in healthy volunteers.
Clin Transl Sci
; 14(6): 2487-2496, 2021 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-34463032
11.
Phase I Study of AMG 337, a Highly Selective Small-molecule MET Inhibitor, in Patients with Advanced Solid Tumors.
Clin Cancer Res
; 25(8): 2403-2413, 2019 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30425090
12.
First-in-Human Study of AMG 820, a Monoclonal Anti-Colony-Stimulating Factor 1 Receptor Antibody, in Patients with Advanced Solid Tumors.
Clin Cancer Res
; 23(19): 5703-5710, 2017 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28655795
13.
In Vitro and In Vivo Activity of AMG 337, a Potent and Selective MET Kinase Inhibitor, in MET-Dependent Cancer Models.
Mol Cancer Ther
; 15(7): 1568-79, 2016 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-27196782
14.
A first-in-human study of AMG 208, an oral MET inhibitor, in adult patients with advanced solid tumors.
Oncotarget
; 6(21): 18693-706, 2015 Jul 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-26155941
15.
Influence of molecular flexibility and polar surface area metrics on oral bioavailability in the rat.
J Med Chem
; 47(24): 6104-7, 2004 Nov 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-15537364
16.
Application of in vivo animal models to characterize the pharmacokinetic and pharmacodynamic properties of drug candidates in discovery settings.
Comb Chem High Throughput Screen
; 13(2): 207-18, 2010 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-20053166
17.
Predicting drug absorption: how nature made it a difficult problem.
J Pharmacol Exp Ther
; 303(3): 889-95, 2002 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-12438506
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