Detalles de la búsqueda
1.
Linear Free Energy Relationships for Enzymatic Reactions: Fresh Insight from a Venerable Probe.
Acc Chem Res
; 54(10): 2532-2542, 2021 05 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-33939414
2.
Phosphodianion Activation of Enzymes for Catalysis of Central Metabolic Reactions.
J Am Chem Soc
; 143(7): 2694-2698, 2021 02 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-33560827
3.
Role of the Carboxylate in Enzyme-Catalyzed Decarboxylation of Orotidine 5'-Monophosphate: Transition State Stabilization Dominates Over Ground State Destabilization.
J Am Chem Soc
; 141(34): 13468-13478, 2019 08 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-31365243
4.
Uncovering the Role of Key Active-Site Side Chains in Catalysis: An Extended Brønsted Relationship for Substrate Deprotonation Catalyzed by Wild-Type and Variants of Triosephosphate Isomerase.
J Am Chem Soc
; 141(40): 16139-16150, 2019 10 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-31508957
5.
Orotidine 5'-Monophosphate Decarboxylase: Probing the Limits of the Possible for Enzyme Catalysis.
Acc Chem Res
; 51(4): 960-969, 2018 04 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-29595949
6.
Enzyme Architecture: The Role of a Flexible Loop in Activation of Glycerol-3-phosphate Dehydrogenase for Catalysis of Hydride Transfer.
Biochemistry
; 57(23): 3227-3236, 2018 06 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-29337541
7.
Primary Deuterium Kinetic Isotope Effects: A Probe for the Origin of the Rate Acceleration for Hydride Transfer Catalyzed by Glycerol-3-Phosphate Dehydrogenase.
Biochemistry
; 57(29): 4338-4348, 2018 07 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-29927590
8.
Enzyme Architecture: Amino Acid Side-Chains That Function To Optimize the Basicity of the Active Site Glutamate of Triosephosphate Isomerase.
J Am Chem Soc
; 140(26): 8277-8286, 2018 07 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-29862813
9.
Enzyme Architecture: Breaking Down the Catalytic Cage that Activates Orotidine 5'-Monophosphate Decarboxylase for Catalysis.
J Am Chem Soc
; 140(50): 17580-17590, 2018 12 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-30475611
10.
Role of Ligand-Driven Conformational Changes in Enzyme Catalysis: Modeling the Reactivity of the Catalytic Cage of Triosephosphate Isomerase.
J Am Chem Soc
; 140(11): 3854-3857, 2018 03 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-29516737
11.
Enzyme Architecture: Erection of Active Orotidine 5'-Monophosphate Decarboxylase by Substrate-Induced Conformational Changes.
J Am Chem Soc
; 139(45): 16048-16051, 2017 11 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29058891
12.
Enzyme Architecture: Modeling the Operation of a Hydrophobic Clamp in Catalysis by Triosephosphate Isomerase.
J Am Chem Soc
; 139(30): 10514-10525, 2017 08 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-28683550
13.
A reevaluation of the origin of the rate acceleration for enzyme-catalyzed hydride transfer.
Org Biomol Chem
; 15(42): 8856-8866, 2017 Oct 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-28956050
14.
Enzyme Architecture: A Startling Role for Asn270 in Glycerol 3-Phosphate Dehydrogenase-Catalyzed Hydride Transfer.
Biochemistry
; 55(10): 1429-32, 2016 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26926520
15.
Structure-Function Studies of Hydrophobic Residues That Clamp a Basic Glutamate Side Chain during Catalysis by Triosephosphate Isomerase.
Biochemistry
; 55(21): 3036-47, 2016 05 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-27149328
16.
Enzyme Architecture: Self-Assembly of Enzyme and Substrate Pieces of Glycerol-3-Phosphate Dehydrogenase into a Robust Catalyst of Hydride Transfer.
J Am Chem Soc
; 138(46): 15251-15259, 2016 11 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-27792325
17.
Structure-Reactivity Effects on Intrinsic Primary Kinetic Isotope Effects for Hydride Transfer Catalyzed by Glycerol-3-phosphate Dehydrogenase.
J Am Chem Soc
; 138(44): 14526-14529, 2016 11 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-27769116
18.
Rate and Equilibrium Constants for an Enzyme Conformational Change during Catalysis by Orotidine 5'-Monophosphate Decarboxylase.
Biochemistry
; 54(29): 4555-64, 2015 Jul 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-26135041
19.
Role of Loop-Clamping Side Chains in Catalysis by Triosephosphate Isomerase.
J Am Chem Soc
; 137(48): 15185-97, 2015 Dec 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-26570983
20.
Enzyme architecture: optimization of transition state stabilization from a cation-phosphodianion pair.
J Am Chem Soc
; 137(16): 5312-5, 2015 Apr 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-25884759