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1.
CD3 Target Affinity Chromatography Mass Spectrometry as a New Tool for Function-Structure Characterization of T-Cell Engaging Bispecific Antibody Proteoforms and Product-Related Variants.
Anal Chem
; 95(4): 2260-2268, 2023 01 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-36638115
2.
Translatability of In Vitro Stress for Predicting Deamidation and Oxidation Biotransformation on Biotherapeutics.
Anal Chem
; 95(49): 17957-17961, 2023 12 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-38084380
3.
Susceptibility of Antibody CDR Residues to Chemical Modifications Can Be Revealed Prior to Antibody Humanization and Aid in the Lead Selection Process.
Mol Pharm
; 15(10): 4529-4537, 2018 10 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30118239
4.
Automated Affinity Capture and On-Tip Digestion to Accurately Quantitate in Vivo Deamidation of Therapeutic Antibodies.
Anal Chem
; 88(23): 11521-11526, 2016 12 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-27797494
5.
Chemical structure and properties of interstrand cross-links formed by reaction of guanine residues with abasic sites in duplex DNA.
J Am Chem Soc
; 137(11): 3933-45, 2015 Mar 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-25710271
6.
Replication across regioisomeric ethylated thymidine lesions by purified DNA polymerases.
Chem Res Toxicol
; 26(11): 1730-8, 2013 Nov 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-24134187
7.
The roles of DNA polymerases κ and ι in the error-free bypass of N2-carboxyalkyl-2'-deoxyguanosine lesions in mammalian cells.
J Biol Chem
; 286(20): 17503-11, 2011 May 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-21454642
8.
In-vitro replication studies on O(2)-methylthymidine and O(4)-methylthymidine.
Chem Res Toxicol
; 25(11): 2523-31, 2012 Nov 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-23113558
9.
Discovery of a dual pathway aggregation mechanism for a therapeutic constrained peptide.
J Pharm Sci
; 110(6): 2362-2371, 2021 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-33652014
10.
From proof of concept to the routine use of an automated and robust multi-dimensional liquid chromatography mass spectrometry workflow applied for the charge variant characterization of therapeutic antibodies.
J Chromatogr A
; 1615: 460740, 2020 Mar 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-31796250
11.
Prediction of methionine oxidation risk in monoclonal antibodies using a machine learning method.
MAbs
; 10(8): 1281-1290, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-30252602
12.
The Use of a 2,2'-Azobis (2-Amidinopropane) Dihydrochloride Stress Model as an Indicator of Oxidation Susceptibility for Monoclonal Antibodies.
J Pharm Sci
; 107(2): 550-558, 2018 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-28989015
13.
High-throughput screening of antibody variants for chemical stability: identification of deamidation-resistant mutants.
MAbs
; 10(7): 1073-1083, 2018 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-30130444
14.
Protein engineering to increase the potential of a therapeutic antibody Fab for long-acting delivery to the eye.
MAbs
; 9(8): 1297-1305, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-28854082
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