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1.
Optimization of physicochemical properties of pyrrolidine GPR40 AgoPAMs results in a differentiated profile with improved pharmacokinetics and reduced off-target activities.
Bioorg Med Chem
; 85: 117273, 2023 05 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-37030194
2.
Synthesis and evaluation of azabicyclo[3.2.1]octane derivatives as potent mixed vasopressin antagonists.
Bioorg Med Chem Lett
; 20(12): 3742-5, 2010 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20471258
3.
Characterization of the novel P-selectin inhibitor PSI-697 [2-(4-chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[h] quinoline-4-carboxylic acid] in vitro and in rodent models of vascular inflammation and thrombosis.
J Pharmacol Exp Ther
; 324(2): 497-506, 2008 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-18024786
4.
Neutralization of plasminogen activator inhibitor I (PAI-1) by the synthetic antagonist PAI-749 via a dual mechanism of action.
Mol Pharmacol
; 72(4): 897-906, 2007 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-17622579
5.
Synthesis and SAR of 2-carboxylic acid indoles as inhibitors of plasminogen activator inhibitor-1.
Bioorg Med Chem Lett
; 15(15): 3514-8, 2005 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-15982877
6.
Evaluation of PAI-039 [{1-benzyl-5-[4-(trifluoromethoxy)phenyl]-1H-indol-3-yl}(oxo)acetic acid], a novel plasminogen activator inhibitor-1 inhibitor, in a canine model of coronary artery thrombosis.
J Pharmacol Exp Ther
; 314(2): 710-6, 2005 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-15860572
7.
Design and synthesis of oxadiazolidinediones as inhibitors of plasminogen activator inhibitor-1.
Bioorg Med Chem Lett
; 14(13): 3477-80, 2004 Jul 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-15177456
8.
WAY-140312 reduces plasma PAI-1 while maintaining normal platelet aggregation.
Biochem Biophys Res Commun
; 311(4): 904-8, 2003 Nov 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-14623266
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