Detalles de la búsqueda
1.
Two Affinity Sites of the Cannabinoid Subtype 2 Receptor Identified by a Novel Homogeneous Binding Assay.
J Pharmacol Exp Ther
; 358(3): 580-7, 2016 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-27358483
2.
The Human Affectome.
Neurosci Biobehav Rev
; 158: 105450, 2024 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-37925091
3.
Epigenetic regulation of milk production in dairy cows.
J Mammary Gland Biol Neoplasia
; 15(1): 101-12, 2010 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-20131087
4.
Brain substrates explain differences in the adoption and degree of financial digitalization.
Sci Rep
; 10(1): 17512, 2020 10 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33060709
5.
The neuroscience of sadness: A multidisciplinary synthesis and collaborative review.
Neurosci Biobehav Rev
; 111: 199-228, 2020 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-32001274
6.
A high density linkage map of the bovine genome.
BMC Genet
; 10: 18, 2009 Apr 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-19393043
7.
Taking Advantage of the Selectivity of Histone Deacetylases and Phosphodiesterase Inhibitors to Design Better Therapeutic Strategies to Treat Alzheimer's Disease.
Front Aging Neurosci
; 11: 149, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-31281249
8.
Targeting CB1 and GPR55 Endocannabinoid Receptors as a Potential Neuroprotective Approach for Parkinson's Disease.
Mol Neurobiol
; 56(8): 5900-5910, 2019 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-30687889
9.
Multitarget Approach for the Treatment of Alzheimer's Disease: Inhibition of Phosphodiesterase 9 (PDE9) and Histone Deacetylases (HDACs) Covering Diverse Selectivity Profiles.
ACS Chem Neurosci
; 10(9): 4076-4101, 2019 09 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-31441641
10.
Discovery of in Vivo Chemical Probes for Treating Alzheimer's Disease: Dual Phosphodiesterase 5 (PDE5) and Class I Histone Deacetylase Selective Inhibitors.
ACS Chem Neurosci
; 10(3): 1765-1782, 2019 03 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-30525452
11.
Glucocerebrosidase Mutations and Synucleinopathies. Potential Role of Sterylglucosides and Relevance of Studying Both GBA1 and GBA2 Genes.
Front Neuroanat
; 12: 52, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-30002620
12.
Phenotypic Screening To Discover Novel Chemical Series as Efficient Antihemorrhagic Agents.
ACS Med Chem Lett
; 9(5): 428-433, 2018 May 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-29795754
13.
Design, synthesis, biological evaluation and in vivo testing of dual phosphodiesterase 5 (PDE5) and histone deacetylase 6 (HDAC6)-selective inhibitors for the treatment of Alzheimer's disease.
Eur J Med Chem
; 150: 506-524, 2018 Apr 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-29549837
14.
CM352 Reduces Brain Damage and Improves Functional Recovery in a Rat Model of Intracerebral Hemorrhage.
J Am Heart Assoc
; 6(6)2017 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28572282
15.
Impact of Scaffold Exploration on Novel Dual-Acting Histone Deacetylases and Phosphodiesterase 5 Inhibitors for the Treatment of Alzheimer's Disease.
ACS Chem Neurosci
; 8(3): 638-661, 2017 03 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27936591
16.
A First-in-Class Small-Molecule that Acts as a Dual Inhibitor of HDAC and PDE5 and that Rescues Hippocampal Synaptic Impairment in Alzheimer's Disease Mice.
Neuropsychopharmacology
; 42(2): 524-539, 2017 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27550730
17.
Discovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs in hematological malignancies.
Nat Commun
; 8: 15424, 2017 05 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-28548080
18.
Neuroprotective Effect of JZL184 in MPP(+)-Treated SH-SY5Y Cells Through CB2 Receptors.
Mol Neurobiol
; 53(4): 2312-9, 2016 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-25976369
19.
Design, Synthesis, and Biological Evaluation of First-in-Class Dual Acting Histone Deacetylases (HDACs) and Phosphodiesterase 5 (PDE5) Inhibitors for the Treatment of Alzheimer's Disease.
J Med Chem
; 59(19): 8967-9004, 2016 10 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-27606546
20.
Discovery and safety profiling of a potent preclinical candidate, (4-[4-[[(3R)-3-(hydroxycarbamoyl)-8-azaspiro[4.5]decan-3-yl]sulfonyl]phenoxy]-N-methylbenzamide) (CM-352), for the prevention and treatment of hemorrhage.
J Med Chem
; 58(7): 2941-57, 2015 Apr 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-25686022