Detalles de la búsqueda
1.
Synthesis and PET Imaging Biodistribution Studies of Radiolabeled Iododiflunisal, a Transthyretin Tetramer Stabilizer, Candidate Drug for Alzheimer's Disease.
Molecules
; 29(2)2024 Jan 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-38257401
2.
Binding of common organic UV-filters to the thyroid hormone transport protein transthyretin using in vitro and in silico studies: Potential implications in health.
Environ Res
; 217: 114836, 2023 01 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-36400222
3.
An Assay for Screening Potential Drug Candidates for Alzheimer's Disease That Act as Chaperones of the Transthyretin and Amyloid-ß Peptides Interaction.
Chemistry
; 26(72): 17462-17469, 2020 Dec 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-32761825
4.
Optimization of kinetic stabilizers of tetrameric transthyretin: A prospective ligand efficiency-guided approach.
Bioorg Med Chem
; 28(23): 115794, 2020 12 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33091848
5.
Preparative Scale Production of Recombinant Human Transthyretin for Biophysical Studies of Protein-Ligand and Protein-Protein Interactions.
Int J Mol Sci
; 21(24)2020 Dec 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-33348885
6.
Undiscovered Roles for Transthyretin: From a Transporter Protein to a New Therapeutic Target for Alzheimer's Disease.
Int J Mol Sci
; 21(6)2020 Mar 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-32197355
7.
Repurposing Benzbromarone for Familial Amyloid Polyneuropathy: A New Transthyretin Tetramer Stabilizer.
Int J Mol Sci
; 21(19)2020 Sep 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-32998442
8.
Role of the sugar moiety on the opioid receptor binding and conformation of a series of enkephalin neoglycopeptides.
Bioorg Med Chem
; 25(7): 2260-2265, 2017 04 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28284867
9.
Optimized Proteomic Mass Spectrometry Characterization of Recombinant Human µ-Opioid Receptor Functionally Expressed in Pichia pastoris Cell Lines.
J Proteome Res
; 14(8): 3162-73, 2015 Aug 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-26090583
10.
Influence of polar side chains modifications on the dual enkephalinase inhibitory activity and conformation of human opiorphin, a pain perception related peptide.
Bioorg Med Chem Lett
; 25(22): 5190-3, 2015 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26463133
11.
Longitudinal evaluation of neuroinflammation and oxidative stress in a mouse model of Alzheimer disease using positron emission tomography.
Alzheimers Res Ther
; 14(1): 80, 2022 06 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-35676734
12.
Synthesis, biological evaluation and structural characterization of novel glycopeptide analogues of nociceptin N/OFQ.
Org Biomol Chem
; 9(17): 6133-42, 2011 Sep 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-21773621
13.
Neuroprotection in early stages of Alzheimer's disease is promoted by transthyretin angiogenic properties.
Alzheimers Res Ther
; 13(1): 143, 2021 08 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-34429155
14.
Targeting transthyretin in Alzheimer's disease: Drug discovery of small-molecule chaperones as disease-modifying drug candidates for Alzheimer's disease.
Eur J Med Chem
; 226: 113847, 2021 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34555615
15.
Does Antigen Glycosylation Impact the HIV-Specific T Cell Immunity?
Front Immunol
; 11: 573928, 2020.
Artículo
en Inglés
| MEDLINE | ID: mdl-33552045
16.
Calorimetric Studies of Binary and Ternary Molecular Interactions between Transthyretin, Aß Peptides, and Small-Molecule Chaperones toward an Alternative Strategy for Alzheimer's Disease Drug Discovery.
J Med Chem
; 63(6): 3205-3214, 2020 03 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-32124607
17.
Oral Treatment with Iododiflunisal Delays Hippocampal Amyloid-ß Formation in a Transgenic Mouse Model of Alzheimer's Disease: A Longitudinal in vivo Molecular Imaging Study1.
J Alzheimers Dis
; 77(1): 99-112, 2020.
Artículo
en Inglés
| MEDLINE | ID: mdl-32804152
18.
Iodination of salicylic acid improves its binding to transthyretin.
Biochim Biophys Acta
; 1784(3): 512-7, 2008 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-18155178
19.
Isatin derivatives, a novel class of transthyretin fibrillogenesis inhibitors.
Bioorg Med Chem Lett
; 19(17): 5270-3, 2009 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19651509
20.
Radiochemical examination of transthyretin (TTR) brain penetration assisted by iododiflunisal, a TTR tetramer stabilizer and a new candidate drug for AD.
Sci Rep
; 9(1): 13672, 2019 09 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-31541162