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1.
A novel, potent dual inhibitor of Arg-gingipains and Lys-gingipain as a promising agent for periodontal disease therapy.
FASEB J
; 28(8): 3564-78, 2014 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-24776743
2.
DNA sequence selective adenine alkylation, mechanism of adduct repair, and in vivo antitumor activity of the novel achiral seco-amino-cyclopropylbenz[e]indolone analogue of duocarmycin AS-I-145.
Mol Cancer Ther
; 6(10): 2708-18, 2007 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-17938264
3.
TAS-108, a novel oral steroidal antiestrogenic agent, is a pure antagonist on estrogen receptor alpha and a partial agonist on estrogen receptor beta with low uterotrophic effect.
Clin Cancer Res
; 11(1): 315-22, 2005 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-15671561
4.
Self-association and unique DNA binding properties of the anti-cancer agent TAS-103, a dual inhibitor of topoisomerases I and II.
Biochim Biophys Acta
; 1587(2-3): 155-63, 2002 Jul 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-12084457
5.
A novel class of in vivo active anticancer agents: achiral seco-amino- and seco-hydroxycyclopropylbenz[e]indolone (seco-CBI) analogues of the duocarmycins and CC-1065.
J Med Chem
; 48(11): 3903-18, 2005 Jun 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-15916443
6.
The anticancer natural product pironetin selectively targets Lys352 of alpha-tubulin.
Chem Biol
; 11(6): 799-806, 2004 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-15217613
7.
Efficient synthesis of achiral seco-cyclopropylbenz[2,3-e]indoline analogues: [4-amino-2-(5,6,7-trimethoxyindole-2-carboxamido)naphthalen-1-yl]ethyl chloride and [4-hydroxy-2-(5,6,7-trimethoxyindole-2-carboxamido)naphthalen-1-yl]ethyl chloride.
J Org Chem
; 71(12): 4692-5, 2006 Jun 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-16749810
8.
DNA interstrand crosslinking agents: synthesis, DNA interactions, and cytotoxicity of dimeric achiral seco-amino-CBI and conjugates of achiral seco-amino-CBI with pyrrolobenzodiazepine (PBD).
Bioorg Med Chem Lett
; 16(21): 5677-81, 2006 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16919946
9.
Synthesis and structure-activity relationship of 4-substituted benzoic acids and their inhibitory effect on the biosynthesis of fatty acids and sterols.
Arch Pharm (Weinheim)
; 338(4): 147-58, 2005 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-15818566
10.
Napthalimidobenzamide DB-51630: a novel DNA binding agent inducing p300 gene expression and exerting a potent anti-cancer activity.
Bioorg Med Chem
; 13(12): 4014-21, 2005 Jun 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-15911314
11.
Roles for Arg- and Lys-gingipains in the disruption of cytokine responses and loss of viability of human endothelial cells by Porphyromonas gingivalis infection.
Biol Chem
; 383(7-8): 1223-30, 2002.
Artículo
en Inglés
| MEDLINE | ID: mdl-12437109
12.
Suppression of pathogenicity of Porphyromonas gingivalis by newly developed gingipain inhibitors.
Mol Pharmacol
; 66(6): 1599-606, 2004 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-15361547
13.
Synthesis and evaluation of 6-methylene-bridged uracil derivatives. Part 1: discovery of novel orally active inhibitors of human thymidine phosphorylase.
Bioorg Med Chem
; 12(13): 3431-41, 2004 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-15186829
14.
Synthesis and evaluation of 6-methylene-bridged uracil derivatives. Part 2: optimization of inhibitors of human thymidine phosphorylase and their selectivity with uridine phosphorylase.
Bioorg Med Chem
; 12(13): 3443-50, 2004 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-15186830
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