Detalles de la búsqueda
1.
Investigation of the absolute bioavailability, mass balance, metabolism, and excretion of the cholesterol 24-hydroxylase inhibitor soticlestat in healthy volunteers.
Br J Clin Pharmacol
; 90(2): 516-527, 2024 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-37771051
2.
Efficacy, safety, and tolerability of soticlestat as adjunctive therapy for the treatment of seizures in patients with Dup15q syndrome or CDKL5 deficiency disorder in an open-label signal-finding phase II study (ARCADE).
Epilepsy Behav
; 142: 109173, 2023 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-37011526
3.
Randomized controlled study to evaluate the efficacy and safety of soticlestat as adjunctive therapy in adults with complex regional pain syndrome.
Pain Med
; 24(7): 872-880, 2023 07 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-36538782
4.
A phase 2, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of soticlestat as adjunctive therapy in pediatric patients with Dravet syndrome or Lennox-Gastaut syndrome (ELEKTRA).
Epilepsia
; 63(10): 2671-2683, 2022 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-35841234
5.
An observational study of rotigotine transdermal patch and other currently prescribed therapies in patients with Parkinson's disease.
J Neural Transm (Vienna)
; 125(6): 953-963, 2018 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-29484495
6.
ICARUS study: prevalence and clinical features of impulse control disorders in Parkinson's disease.
J Neurol Neurosurg Psychiatry
; 88(4): 317-324, 2017 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-28315845
7.
Evaluation of rotigotine transdermal patch for the treatment of apathy and motor symptoms in Parkinson's disease.
BMC Neurol
; 16: 90, 2016 Jun 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-27267880
8.
Population pharmacokinetics, enzyme occupancy, and pharmacodynamic modeling of soticlestat in patients with developmental and epileptic encephalopathies.
Clin Transl Sci
; 17(3): e13722, 2024 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-38445548
9.
Population pharmacokinetics, enzyme occupancy, and 24S-hydroxycholesterol modeling of soticlestat, a novel cholesterol 24-hydroxylase inhibitor, in healthy adults.
Clin Transl Sci
; 16(7): 1149-1162, 2023 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-37212649
10.
The D-amino acid oxidase inhibitor luvadaxistat improves mismatch negativity in patients with schizophrenia in a randomized trial.
Neuropsychopharmacology
; 48(7): 1052-1059, 2023 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-36928351
11.
Central nervous system effects of TAK-653, an investigational alpha-amino-3-hydroxy-5-methyl-4-isoxazole receptor (AMPAR) positive allosteric modulator in healthy volunteers.
Transl Psychiatry
; 12(1): 408, 2022 09 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-36153330
12.
A phase 1b/2a study of soticlestat as adjunctive therapy in participants with developmental and/or epileptic encephalopathies.
Epilepsy Res
; 174: 106646, 2021 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-33940389
13.
Transcranial magnetic stimulation as a translational biomarker for AMPA receptor modulation.
Transl Psychiatry
; 11(1): 325, 2021 05 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-34045439
14.
The characteristics and treatment patterns of patients with Parkinson's disease in the United States and United Kingdom: A retrospective cohort study.
PLoS One
; 14(11): e0225723, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-31756215
15.
Risk factors for impulse control disorders and related behaviors in Parkinson's disease: secondary analyses of the ICARUS study.
J Drug Assess
; 8(1): 159-166, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-31700703
16.
Pharmacokinetics, Tolerability, and Bioequivalence of Two Formulations of Rotigotine in Healthy Chinese Subjects.
Clin Ther
; 40(7): 1108-1121.e8, 2018 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-30098648
17.
A noninterventional study evaluating the effectiveness of rotigotine and levodopa combination therapy in younger versus older patients with Parkinson's disease.
Expert Opin Pharmacother
; 19(9): 937-945, 2018 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-29916262
18.
Switching from an oral dopamine receptor agonist to rotigotine transdermal patch: a review of clinical data with a focus on patient perspective.
Expert Rev Neurother
; 17(7): 737-749, 2017 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-28548894
19.
Rotigotine transdermal patch in Chinese patients with advanced Parkinson's disease: A randomized, double-blind, placebo-controlled pivotal study.
Parkinsonism Relat Disord
; 44: 6-12, 2017 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-28827011
20.
Comparing the Incidence of Falls/Fractures in Parkinson's Disease Patients in the US Population.
PLoS One
; 11(9): e0161689, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-27583564