Detalles de la búsqueda
1.
A minimal physiologically based pharmacokinetic model to study the combined effect of antibody size, charge, and binding affinity to FcRn/antigen on antibody pharmacokinetics.
J Pharmacokinet Pharmacodyn
; 2024 Feb 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-38400996
2.
Mechanistic incorporation of FcRn binding in plasma and endosomes in a whole body PBPK model for large molecules.
J Pharmacokinet Pharmacodyn
; 50(3): 229-241, 2023 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-36877385
3.
Pharmacological activation of myosin II paralogs to correct cell mechanics defects.
Proc Natl Acad Sci U S A
; 112(5): 1428-33, 2015 Feb 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-25605895
4.
Valproic acid is a novel activator of AMP-activated protein kinase and decreases liver mass, hepatic fat accumulation, and serum glucose in obese mice.
Mol Pharmacol
; 85(1): 1-10, 2014 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-24105977
5.
Human biotransformation of the nonnucleoside reverse transcriptase inhibitor rilpivirine and a cross-species metabolism comparison.
Antimicrob Agents Chemother
; 57(10): 5067-79, 2013 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-23917319
6.
Compartmentalization and antiviral effect of efavirenz metabolites in blood plasma, seminal plasma, and cerebrospinal fluid.
Drug Metab Dispos
; 41(2): 422-9, 2013 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-23166317
7.
Dendritic spine injury induced by the 8-hydroxy metabolite of efavirenz.
J Pharmacol Exp Ther
; 343(3): 696-703, 2012 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-22984227
8.
A Physiologically-Based Pharmacokinetic Model for the Prediction of Monoclonal Antibody Pharmacokinetics From In Vitro Data.
CPT Pharmacometrics Syst Pharmacol
; 8(10): 738-747, 2019 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31464379
9.
Changes in complementarity-determining regions significantly alter IgG binding to the neonatal Fc receptor (FcRn) and pharmacokinetics.
MAbs
; 10(1): 81-94, 2018 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28991504
10.
Linear pharmacokinetic parameters for monoclonal antibodies are similar within a species and across different pharmacological targets: A comparison between human, cynomolgus monkey and hFcRn Tg32 transgenic mouse using a population-modeling approach.
MAbs
; 10(5): 751-764, 2018 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-29634430
11.
Establishing in vitro in vivo correlations to screen monoclonal antibodies for physicochemical properties related to favorable human pharmacokinetics.
MAbs
; 10(2): 244-255, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-29271699
12.
Tissue expression profile of human neonatal Fc receptor (FcRn) in Tg32 transgenic mice.
MAbs
; 8(5): 848-53, 2016 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-27104806
13.
Utility of a human FcRn transgenic mouse model in drug discovery for early assessment and prediction of human pharmacokinetics of monoclonal antibodies.
MAbs
; 8(6): 1064-78, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-27232760
14.
A selective phenelzine analogue inhibitor of histone demethylase LSD1.
ACS Chem Biol
; 9(6): 1284-93, 2014 Jun 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-24707965
15.
Increasing extracellular protein concentration reduces intracellular antiretroviral drug concentration and antiviral effect.
AIDS Res Hum Retroviruses
; 29(11): 1434-42, 2013 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-23601085
16.
Neuroprotective maraviroc monotherapy in simian immunodeficiency virus-infected macaques: reduced replicating and latent SIV in the brain.
AIDS
; 27(18): F21-8, 2013 Nov 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-24051706
17.
A highly sensitive ultra performance liquid chromatography-tandem mass spectrometric (UPLC-MS/MS) technique for quantitation of protein free and bound efavirenz (EFV) in human seminal and blood plasma.
J Chromatogr B Analyt Technol Biomed Life Sci
; 878(31): 3217-24, 2010 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21036679
Resultados
1 -
17
de 17
1
Próxima >
>>