Detalles de la búsqueda
1.
Metabolic Profiling of S-praziquantel: Structure Elucidation Using the Crystalline Sponge Method in Combination with Mass Spectrometry and Nuclear Magnetic Resonance.
Drug Metab Dispos
; 50(4): 320-326, 2022 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-35115299
2.
Translation of liver stage activity of M5717, a Plasmodium elongation factor 2 inhibitor: from bench to bedside.
Malar J
; 21(1): 151, 2022 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-35570264
3.
Deconvolution of Cytochrome P450 Induction Mechanisms in HepaRG Nuclear Hormone Receptor Knockout Cells.
Drug Metab Dispos
; 49(8): 668-678, 2021 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-34035124
4.
Preclinical Antimalarial Combination Study of M5717, a Plasmodium falciparum Elongation Factor 2 Inhibitor, and Pyronaridine, a Hemozoin Formation Inhibitor.
Antimicrob Agents Chemother
; 64(4)2020 03 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-32041711
5.
Crystalline Sponges as a Sensitive and Fast Method for Metabolite Identification: Application to Gemfibrozil and its Phase I and II Metabolites.
Drug Metab Dispos
; 48(7): 587-593, 2020 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-32434832
6.
Prediction of volume of distribution in humans: analysis of eight methods and their application in drug discovery.
Xenobiotica
; 50(3): 270-279, 2020 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-31215316
7.
Improved Prediction of in Vivo Supersaturation and Precipitation of Poorly Soluble Weakly Basic Drugs Using a Biorelevant Bicarbonate Buffer in a Gastrointestinal Transfer Model.
Mol Pharm
; 16(9): 3938-3947, 2019 09 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-31335153
8.
Parkinson's disease-like burst firing activity in subthalamic nucleus induced by AAV-α-synuclein is normalized by LRRK2 modulation.
Neurobiol Dis
; 116: 13-27, 2018 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-29680709
9.
A small molecule activator of Nav 1.1 channels increases fast-spiking interneuron excitability and GABAergic transmission in vitro and has anti-convulsive effects in vivo.
Eur J Neurosci
; 46(3): 1887-1896, 2017 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-28635024
10.
The design and SAR of a novel series of 2-aminopyridine based LRRK2 inhibitors.
Bioorg Med Chem Lett
; 27(18): 4500-4505, 2017 09 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28802631
11.
An invertebrate model for CNS drug discovery: Transcriptomic and functional analysis of a mammalian P-glycoprotein ortholog.
Biochim Biophys Acta
; 1850(12): 2439-51, 2015 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-26363463
12.
Linking HSP90 target occupancy to HSP70 induction and efficacy in mouse brain.
Pharmacol Res
; 104: 197-205, 2016 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-26731018
13.
Characterization of midazolam metabolism in locusts: the role of a CYP3A4-like enzyme in the formation of 1'-OH and 4-OH midazolam.
Xenobiotica
; 46(2): 99-107, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-26207435
14.
Evaluation of 309 molecules as inducers of CYP3A4, CYP2B6, CYP1A2, OATP1B1, OCT1, MDR1, MRP2, MRP3 and BCRP in cryopreserved human hepatocytes in sandwich culture.
Xenobiotica
; 45(2): 177-87, 2015 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-25183402
15.
Identification of a functional homolog of the mammalian CYP3A4 in locusts.
Drug Metab Dispos
; 42(7): 1153-62, 2014 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-24778367
16.
The grasshopper: a novel model for assessing vertebrate brain uptake.
J Pharmacol Exp Ther
; 346(2): 211-8, 2013 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-23671124
17.
Screening novel CNS drug candidates for P-glycoprotein interactions using the cell line iP-gp: In vitro efflux ratios from iP-gp and MDCK-MDR1 monolayers compared to brain distribution data from mice.
Eur J Pharm Biopharm
; 169: 211-219, 2021 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-34756975
18.
Crystalline sponge affinity screening: A fast tool for soaking condition optimization without the need of X-ray diffraction analysis.
Eur J Pharm Sci
; 164: 105884, 2021 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34161782
19.
Design and Synthesis of Pyrrolo[2,3-d]pyrimidine-Derived Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Checkpoint Kinase 1 (CHK1)-Derived Crystallographic Surrogate.
J Med Chem
; 64(14): 10312-10332, 2021 07 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-34184879
20.
Synthesis and Characterization of the Novel Rodent-Active and CNS-Penetrant P2X7 Receptor Antagonist Lu AF27139.
J Med Chem
; 64(8): 4891-4902, 2021 04 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-33822617