Detalles de la búsqueda
1.
Structure Guided Design, Synthesis, and Biological Evaluation of Oxetane-Containing Indole Analogues.
Bioorg Med Chem
; 92: 117400, 2023 09 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-37556912
2.
The interaction of spongistatin 1 with tubulin.
Arch Biochem Biophys
; 727: 109296, 2022 09 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-35594923
3.
Novel pyrazolo[4,3-d]pyrimidine microtubule targeting agents (MTAs): Synthesis, structure-activity relationship, in vitro and in vivo evaluation as antitumor agents.
Bioorg Med Chem Lett
; 41: 127923, 2021 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33705908
4.
Interaction of diazonamide A with tubulin.
Arch Biochem Biophys
; 680: 108217, 2020 02 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31830440
5.
Diaryl disulfides and thiosulfonates as combretastatin A-4 analogues: Synthesis, cytotoxicity and antitubulin activity.
Bioorg Chem
; 101: 104017, 2020 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-32629276
6.
12,13-Aziridinyl Epothilones. Stereoselective Synthesis of Trisubstituted Olefinic Bonds from Methyl Ketones and Heteroaromatic Phosphonates and Design, Synthesis, and Biological Evaluation of Potent Antitumor Agents.
J Am Chem Soc
; 139(21): 7318-7334, 2017 05 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-28513142
7.
Corrigendum to "The interaction of spongistatin 1 with tubulin" [Arch. Biochem. Biophys. 727 (2022) 109296 (7 pages)].
Arch Biochem Biophys
; 730: 109412, 2022 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-36175266
8.
Discovery and preclinical evaluation of 7-benzyl-N-(substituted)-pyrrolo[3,2-d]pyrimidin-4-amines as single agents with microtubule targeting effects along with triple-acting angiokinase inhibition as antitumor agents.
Bioorg Med Chem
; 25(2): 545-556, 2017 01 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27894589
9.
(-)-Rhazinilam and the diphenylpyridazinone NSC 613241: Two compounds inducing the formation of morphologically similar tubulin spirals but binding apparently to two distinct sites on tubulin.
Arch Biochem Biophys
; 604: 63-73, 2016 08 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27311615
10.
Complementary isonitrile-based multicomponent reactions for the synthesis of diversified cytotoxic hemiasterlin analogues.
Org Biomol Chem
; 13(48): 11633-44, 2015 Dec 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-26467486
11.
Synthesis, antiproliferative activity and possible mechanism of action of novel 2-acetamidobenzamides bearing the 2-phenoxy functionality.
Bioorg Med Chem
; 23(19): 6305-16, 2015 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26344588
12.
Antiproliferative 4-(1,2,4-oxadiazol-5-yl)piperidine-1-carboxamides, a new tubulin inhibitor chemotype.
Bioorg Med Chem Lett
; 24(18): 4477-4481, 2014 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25155551
13.
Synthesis and biological evaluation of structurally diverse 6-aryl-3-aroyl-indole analogues as inhibitors of tubulin polymerization.
Eur J Med Chem
; 263: 115794, 2024 Jan 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-37984295
14.
Copper(II) Complexes with Isomeric Morpholine-Substituted 2-Formylpyridine Thiosemicarbazone Hybrids as Potential Anticancer Drugs Inhibiting Both Ribonucleotide Reductase and Tubulin Polymerization: The Morpholine Position Matters.
J Med Chem
; 67(11): 9069-9090, 2024 Jun 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-38771959
15.
Synthesis and evaluation of diaryl sulfides and diaryl selenide compounds for antitubulin and cytotoxic activity.
Bioorg Med Chem Lett
; 23(16): 4669-73, 2013 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23810282
16.
Indolo[2,3-e]benzazocines and indolo[2,3-f]benzazonines and their copper(II) complexes as microtubule destabilizing agents.
Dalton Trans
; 52(29): 9964-9982, 2023 Jul 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-37431840
17.
Identification of pyrrolo[3',4':3,4]cyclohepta[1,2-d][1,2]oxazoles as promising new candidates for the treatment of lymphomas.
Eur J Med Chem
; 254: 115372, 2023 Jun 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-37068384
18.
RS6077 induces mitotic arrest and selectively activates cell death in human cancer cell lines and in a lymphoma tumor in vivo.
Eur J Med Chem
; 246: 114997, 2023 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-36502578
19.
4-(3-Phenyl-4-(3,4,5-trimethoxybenzoyl)-1H-pyrrol-1-yl)benzenesulfonamide, a Novel Carbonic Anhydrase and Wnt/ß-Catenin Signaling Pathway Dual-Targeting Inhibitor with Potent Activity against Multidrug Resistant Cancer Cells.
J Med Chem
; 66(21): 14824-14842, 2023 11 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-37902628
20.
Total Synthesis of Potent Antitumor Macrolide, (-)-Zampanolide: An Oxidative Intramolecular Cyclization-Based Strategy.
European J Org Chem
; 2012(22): 4130-4139, 2012 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23606808