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1.
Pharmacokinetics of fostamatinib, a spleen tyrosine kinase (SYK) inhibitor, in healthy human subjects following single and multiple oral dosing in three phase I studies.
Br J Clin Pharmacol
; 76(1): 78-88, 2013 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-23190017
2.
Metabolism of fostamatinib, the oral methylene phosphate prodrug of the spleen tyrosine kinase inhibitor R406 in humans: contribution of hepatic and gut bacterial processes to the overall biotransformation.
Drug Metab Dispos
; 38(7): 1166-76, 2010 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-20371637
3.
Developmental toxicity associated with receptor tyrosine kinase Ret inhibition in reproductive toxicity testing.
Birth Defects Res A Clin Mol Teratol
; 85(2): 130-6, 2009 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-19107952
4.
Effects of CYP3A4 Inhibitors Ketoconazole and Verapamil and the CYP3A4 Inducer Rifampicin on the Pharmacokinetic Parameters of Fostamatinib: Results from In Vitro and Phase I Clinical Studies.
Drugs R D
; 16(1): 81-92, 2016 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-26739683
5.
Cyclosporine pharmacokinetics and dosing modifications in human immunodeficiency virus-infected liver and kidney transplant recipients.
Transplantation
; 80(1): 13-7, 2005 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-16003227
6.
Effects of Fostamatinib on the Pharmacokinetics of Digoxin (a P-Glycoprotein Substrate): Results From in Vitro and Phase I Clinical Studies.
Clin Ther
; 37(12): 2811-22, 2015 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26514315
7.
Significant reduction of acute cardiac allograft rejection by selective janus kinase-1/3 inhibition using R507 and R545.
Transplantation
; 94(7): 695-702, 2012 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22971540
8.
Fostamatinib, a Syk-kinase inhibitor, does not affect methotrexate pharmacokinetics in patients with rheumatoid arthritis.
J Clin Pharmacol
; 51(9): 1310-8, 2011 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-21209239
9.
Preclinical characterization of Aurora kinase inhibitor R763/AS703569 identified through an image-based phenotypic screen.
J Cancer Res Clin Oncol
; 136(1): 99-113, 2010 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-19609559
10.
An orally bioavailable spleen tyrosine kinase inhibitor delays disease progression and prolongs survival in murine lupus.
Arthritis Rheum
; 58(5): 1433-44, 2008 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-18438845
11.
R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation.
J Pharmacol Exp Ther
; 319(3): 998-1008, 2006 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-16946104
12.
The effect of soluble complement receptor type 1 on acute humoral xenograft rejection in hDAF-transgenic pig-to-primate life-supporting kidney xenografts.
Xenotransplantation
; 12(1): 20-9, 2005 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-15598270
13.
Novel percutaneous adventitial drug delivery system for regional vascular treatment.
Catheter Cardiovasc Interv
; 63(2): 222-30, 2004 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-15390346
14.
Automated, fast, and sensitive quantification of drugs in human plasma by LC/LC-MS: quantification of 6 protease inhibitors and 3 nonnucleoside transcriptase inhibitors.
Ther Drug Monit
; 26(5): 546-62, 2004 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-15385839
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