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Discovery of 3-[2-(imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide (AP24534), a potent, orally active pan-inhibitor of breakpoint cluster region-abelson (BCR-ABL) kinase including the T315I gatekeeper mutant.
J Med Chem
; 53(12): 4701-19, 2010 Jun 24.
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| MEDLINE | ID: mdl-20513156
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9-(Arenethenyl)purines as dual Src/Abl kinase inhibitors targeting the inactive conformation: design, synthesis, and biological evaluation.
J Med Chem
; 52(15): 4743-56, 2009 Aug 13.
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en Inglés
| MEDLINE | ID: mdl-19572547
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