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1.
ROCK inhibitors 4: Structure-activity relationship studies of 7-azaindole-based rho kinase (ROCK) inhibitors.
Bioorg Med Chem Lett
; 33: 127721, 2021 02 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33259926
2.
Application of a Dual Catalytic Nickel/Iridium-Based Photoredox Reaction to Synthesize 2-Alkyl-N-Arylindoles in a Continuous Flow.
J Org Chem
; 85(19): 12644-12656, 2020 10 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-32915566
3.
Generation of Diversity Sets with High sp3 Fraction Using the Photoredox Coupling of Organotrifluoroborates and Organosilicates with Heteroaryl/Aryl Bromides in Continuous Flow.
J Org Chem
; 83(3): 1551-1557, 2018 02 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-29281285
4.
ROCK inhibitors 2. Improving potency, selectivity and solubility through the application of rationally designed solubilizing groups.
Bioorg Med Chem Lett
; 28(15): 2616-2621, 2018 08 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29945794
5.
ROCK inhibitors 3: Design, synthesis and structure-activity relationships of 7-azaindole-based Rho kinase (ROCK) inhibitors.
Bioorg Med Chem Lett
; 28(15): 2622-2626, 2018 08 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30082069
6.
Application of the Photoredox Coupling of Trifluoroborates and Aryl Bromides to Analog Generation Using Continuous Flow.
J Org Chem
; 81(24): 12525-12531, 2016 12 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-27978728
7.
Isosteric replacements of the carboxylic acid of drug candidate VX-787: Effect of charge on antiviral potency and kinase activity of azaindole-based influenza PB2 inhibitors.
Bioorg Med Chem Lett
; 25(9): 1990-4, 2015 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25827523
8.
Discovery of a Novel Series of Potent and Selective Alkynylthiazole-Derived PI3Kγ Inhibitors.
ACS Med Chem Lett
; 12(1): 129-135, 2021 Jan 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-33488974
9.
Novel thiol-based TACE inhibitors. Part 2: Rational design, synthesis, and SAR of thiol-containing aryl sulfones.
Bioorg Med Chem Lett
; 18(1): 44-8, 2008 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18054488
10.
Design and Synthesis of a Novel Series of Orally Bioavailable, CNS-Penetrant, Isoform Selective Phosphoinositide 3-Kinase γ (PI3Kγ) Inhibitors with Potential for the Treatment of Multiple Sclerosis (MS).
J Med Chem
; 61(12): 5245-5256, 2018 06 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-29847724
11.
Novel 2-Substituted 7-Azaindole and 7-Azaindazole Analogues as Potential Antiviral Agents for the Treatment of Influenza.
ACS Med Chem Lett
; 8(2): 261-265, 2017 Feb 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-28197323
12.
Discovery of Novel, Orally Bioavailable ß-Amino Acid Azaindole Inhibitors of Influenza PB2.
ACS Med Chem Lett
; 8(2): 256-260, 2017 Feb 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-28197322
13.
Synthesis of Cycloalkyl Substituted 7-Azaindoles via Photoredox Nickel Dual Catalytic Cross-Coupling in Batch and Continuous Flow.
Org Lett
; 18(23): 6180-6183, 2016 12 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-27934358
14.
Fragment-Based Discovery of Dual JC Virus and BK Virus Helicase Inhibitors.
J Med Chem
; 59(15): 7138-51, 2016 08 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-27385654
15.
Design, Synthesis, and Structure-Activity Relationships of Pyridine-Based Rho Kinase (ROCK) Inhibitors.
J Med Chem
; 58(12): 5028-37, 2015 Jun 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-26039570
16.
Discovery of Highly Isoform Selective Thiazolopiperidine Inhibitors of Phosphoinositide 3-Kinase γ.
J Med Chem
; 58(14): 5684-8, 2015 Jul 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-26121481
17.
Synthesis and selective cyclooxygenase-2 inhibitory activity of a series of novel, nitric oxide donor-containing pyrazoles.
J Med Chem
; 47(9): 2180-93, 2004 Apr 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-15084117
18.
Discovery of a novel, first-in-class, orally bioavailable azaindole inhibitor (VX-787) of influenza PB2.
J Med Chem
; 57(15): 6668-78, 2014 Aug 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-25019388
19.
Novel thiol-based TACE inhibitors: rational design, synthesis, and SAR of thiol-containing aryl sulfonamides.
Bioorg Med Chem Lett
; 17(8): 2250-3, 2007 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17289381
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