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1.
Partial deletion of ROCK2 protects mice from high-fat diet-induced cardiac insulin resistance and contractile dysfunction.
Am J Physiol Heart Circ Physiol
; 309(1): H70-81, 2015 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25910808
2.
Diabetes-induced increased oxidative stress in cardiomyocytes is sustained by a positive feedback loop involving Rho kinase and PKCß2.
Am J Physiol Heart Circ Physiol
; 303(8): H989-H1000, 2012 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22865386
3.
NBI-921352, a first-in-class, NaV1.6 selective, sodium channel inhibitor that prevents seizures in Scn8a gain-of-function mice, and wild-type mice and rats.
Elife
; 112022 03 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-35234610
4.
Discovery of Acyl-sulfonamide Nav1.7 Inhibitors GDC-0276 and GDC-0310.
J Med Chem
; 64(6): 2953-2966, 2021 03 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-33682420
5.
Structure- and Ligand-Based Discovery of Chromane Arylsulfonamide Nav1.7 Inhibitors for the Treatment of Chronic Pain.
J Med Chem
; 62(8): 4091-4109, 2019 04 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-30943032
6.
Identification of Selective Acyl Sulfonamide-Cycloalkylether Inhibitors of the Voltage-Gated Sodium Channel (NaV) 1.7 with Potent Analgesic Activity.
J Med Chem
; 62(2): 908-927, 2019 01 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-30499663
7.
Selective NaV1.7 Antagonists with Long Residence Time Show Improved Efficacy against Inflammatory and Neuropathic Pain.
Cell Rep
; 24(12): 3133-3145, 2018 09 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-30231997
8.
Design of Conformationally Constrained Acyl Sulfonamide Isosteres: Identification of N-([1,2,4]Triazolo[4,3- a]pyridin-3-yl)methane-sulfonamides as Potent and Selective hNaV1.7 Inhibitors for the Treatment of Pain.
J Med Chem
; 61(11): 4810-4831, 2018 06 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-29737846
9.
Discovery of Aryl Sulfonamides as Isoform-Selective Inhibitors of NaV1.7 with Efficacy in Rodent Pain Models.
ACS Med Chem Lett
; 7(3): 277-82, 2016 Mar 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-26985315
10.
Contribution of Rho kinase to blood pressure elevation and vasoconstrictor responsiveness in type 2 diabetic Goto-Kakizaki rats.
J Hypertens
; 31(6): 1160-9, 2013 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-23552123
11.
Vasorelaxant and antihypertensive effect of Cocos nucifera Linn. endocarp on isolated rat thoracic aorta and DOCA salt-induced hypertensive rats.
J Ethnopharmacol
; 134(1): 50-4, 2011 Mar 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-21129472
12.
A possible correlation between the correction of endothelial dysfunction and normalization of high blood pressure levels by 1,3,4-oxadiazole derivative, an L-type Ca2+ channel blocker in deoxycorticosterone acetate and N(G)-nitro-l-arginine hypertensive rats.
Chem Biol Interact
; 183(2): 327-31, 2010 Jan 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-19912999
13.
Vasorelaxant effect in rat aortic rings through calcium channel blockage: a preliminary in vitro assessment of a 1,3,4-oxadiazole derivative.
Chem Biol Interact
; 181(3): 377-82, 2009 Oct 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-19643099
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