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1.
Discovery of Proteolysis-Targeting Chimera Molecules that Selectively Degrade the IRAK3 Pseudokinase.
J Med Chem
; 63(18): 10460-10473, 2020 09 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-32803978
2.
The Pharmacokinetic-Pharmacodynamic (PKPD) Relationships of AZD3229, a Novel and Selective Inhibitor of KIT, in a Range of Mouse Xenograft Models of GIST.
Clin Cancer Res
; 26(14): 3751-3759, 2020 07 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-32220888
3.
Discovery and pharmacological characterization of AZD3229, a potent KIT/PDGFRα inhibitor for treatment of gastrointestinal stromal tumors.
Sci Transl Med
; 12(541)2020 04 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-32350132
4.
Discovery of (2R)-N-[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1H-indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent and Selective Janus Kinase 1 Inhibitor.
J Med Chem
; 63(9): 4517-4527, 2020 05 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-32297743
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