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1.
Discovery of potent selective bioavailable phosphodiesterase 2 (PDE2) inhibitors active in an osteoarthritis pain model. Part II: optimization studies and demonstration of in vivo efficacy.
Bioorg Med Chem Lett
; 23(11): 3443-7, 2013 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23597790
2.
Discovery of potent, selective, bioavailable phosphodiesterase 2 (PDE2) inhibitors active in an osteoarthritis pain model, part I: transformation of selective pyrazolodiazepinone phosphodiesterase 4 (PDE4) inhibitors into selective PDE2 inhibitors.
Bioorg Med Chem Lett
; 23(11): 3438-42, 2013 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23582272
3.
A class of selective antibacterials derived from a protein kinase inhibitor pharmacophore.
Proc Natl Acad Sci U S A
; 106(6): 1737-42, 2009 Feb 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-19164768
4.
Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition.
Nat Struct Mol Biol
; 11(12): 1192-7, 2004 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-15543157
5.
Rational protein engineering in action: the first crystal structure of a phenylalanine tRNA synthetase from Staphylococcus haemolyticus.
J Struct Biol
; 162(1): 152-69, 2008 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-18086534
6.
Characterization of substrate binding and catalysis in the potential antibacterial target N-acetylglucosamine-1-phosphate uridyltransferase (GlmU).
Protein Sci
; 16(12): 2657-66, 2007 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-18029420
7.
Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects.
J Biol Chem
; 282(38): 27781-91, 2007 Sep 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-17623656
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