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1.

Strain-Dependent Variability of Early Discovery Small Molecule Pharmacokinetics in Mice: Does Strain Matter?

Barr, John T; Tran, Thuy B; Rock, Brooke M; Wahlstrom, Jan L; Dahal, Upendra P.

Drug Metab Dispos ; 48(8): 613-621, 2020 08.

Artículo en Inglés | MEDLINE | ID: mdl-32474442

2.

Mechanistic Studies of Cytochrome P450 3A4 Time-Dependent Inhibition Using Two Cysteine-Targeting Electrophiles.

Barr, John T; Wang, Zhican; Min, Xiaoshan; Wienkers, Henry J; Rock, Brooke M; Rock, Dan A; Wienkers, Larry C.

Drug Metab Dispos ; 48(6): 508-514, 2020 06.

Artículo en Inglés | MEDLINE | ID: mdl-32193357

3.

Fraction Unbound for Liver Microsome and Hepatocyte Incubations for All Major Species Can Be Approximated Using a Single-Species Surrogate.

Barr, John T; Lade, Julie M; Tran, Thuy B; Dahal, Upendra P.

Drug Metab Dispos ; 47(4): 419-423, 2019 04.

Artículo en Inglés | MEDLINE | ID: mdl-30733251

4.

Determination of the Structure and Catalytic Mechanism of Sorghum bicolor Caffeic Acid O-Methyltransferase and the Structural Impact of Three brown midrib12 Mutations.

Green, Abigail R; Lewis, Kevin M; Barr, John T; Jones, Jeffrey P; Lu, Fachuang; Ralph, John; Vermerris, Wilfred; Sattler, Scott E; Kang, ChulHee.

Plant Physiol ; 165(4): 1440-1456, 2014 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-24948836

5.

Inhibition of human aldehyde oxidase activity by diet-derived constituents: structural influence, enzyme-ligand interactions, and clinical relevance.

Barr, John T; Jones, Jeffrey P; Oberlies, Nicholas H; Paine, Mary F.

Drug Metab Dispos ; 43(1): 34-41, 2015 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-25326286

6.

A novel reaction mediated by human aldehyde oxidase: amide hydrolysis of GDC-0834.

Sodhi, Jasleen K; Wong, Susan; Kirkpatrick, Donald S; Liu, Lichuan; Khojasteh, S Cyrus; Hop, Cornelis E C A; Barr, John T; Jones, Jeffrey P; Halladay, Jason S.

Drug Metab Dispos ; 43(6): 908-15, 2015 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-25845827

7.

Why do most human liver cytosol preparations lack xanthine oxidase activity?

Barr, John T; Choughule, Kanika V; Nepal, Sahadev; Wong, Timothy; Chaudhry, Amarjit S; Joswig-Jones, Carolyn A; Zientek, Michael; Strom, Stephen C; Schuetz, Erin G; Thummel, Kenneth E; Jones, Jeffrey P.

Drug Metab Dispos ; 42(4): 695-9, 2014 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-24430612

8.

Evidence for substrate-dependent inhibition profiles for human liver aldehyde oxidase.

Barr, John T; Jones, Jeffrey P.

Drug Metab Dispos ; 41(1): 24-9, 2013 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-22996261

9.

Evaluation of rhesus monkey and guinea pig hepatic cytosol fractions as models for human aldehyde oxidase.

Choughule, Kanika V; Barr, John T; Jones, Jeffrey P.

Drug Metab Dispos ; 41(10): 1852-8, 2013 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-23918666

10.

Absolute quantification of aldehyde oxidase protein in human liver using liquid chromatography-tandem mass spectrometry.

Barr, John T; Jones, Jeffrey P; Joswig-Jones, Carolyn A; Rock, Dan A.

Mol Pharm ; 10(10): 3842-9, 2013 Oct 07.

Artículo en Inglés | MEDLINE | ID: mdl-24006961

11.

Inhibition of human liver aldehyde oxidase: implications for potential drug-drug interactions.

Barr, John T; Jones, Jeffrey P.

Drug Metab Dispos ; 39(12): 2381-6, 2011 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-21940905

12.

Case Study 1: Practical Considerations with Experimental Design and Interpretation.

Barr, John T; Iwuchukwu, Otito F.

Methods Mol Biol ; 2342: 633-642, 2021.

Artículo en Inglés | MEDLINE | ID: mdl-34272708

13.

Enzyme Kinetics, Pharmacokinetics, and Inhibition of Aldehyde Oxidase.

Paragas, Erickson M; Choughule, Kanika; Jones, Jeffrey P; Barr, John T.

Methods Mol Biol ; 2342: 257-284, 2021.

Artículo en Inglés | MEDLINE | ID: mdl-34272698

14.

Enzyme kinetics, inhibition, and regioselectivity of aldehyde oxidase.

Barr, John T; Choughule, Kanika; Jones, Jeffrey P.

Methods Mol Biol ; 1113: 167-86, 2014.

Artículo en Inglés | MEDLINE | ID: mdl-24523113

15.

Case study 1. Practical considerations with experimental design and interpretation.

Barr, John T; Flora, Darcy R; Iwuchukwu, Otito F.

Methods Mol Biol ; 1113: 419-29, 2014.

Artículo en Inglés | MEDLINE | ID: mdl-24523122

16.

Potential role of cardiac calsequestrin in the lethal arrhythmic effects of cocaine.

Sanchez, Emiliano J; Hayes, Robert P; Barr, John T; Lewis, Kevin M; Webb, Brian N; Subramanian, Arun K; Nissen, Mark S; Jones, Jeffrey P; Shelden, Eric A; Sorg, Barbara A; Fill, Michael; Schenk, James O; Kang, Chulhee.

Drug Alcohol Depend ; 133(2): 344-51, 2013 Dec 01.

Artículo en Inglés | MEDLINE | ID: mdl-23876860

17.

A retrospective look at the carcinogenic potency of vinyl chloride

Barr, John T.

In. Lave, Lester B., ed. Risk assessment and management. New York, U.S. Plenum Press, 1987. p.19-25.

Monografía en En | Desastres | ID: des-9824

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