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1.
Linaclotide Reduced Response Time for Irritable Bowel Syndrome With Constipation Symptoms: Analysis of 4 Randomized Controlled Trials.
Am J Gastroenterol
; 118(5): 872-879, 2023 05 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36227782
2.
Efficacy of Linaclotide in Reducing Abdominal Symptoms of Bloating, Discomfort, and Pain: A Phase 3B Trial Using a Novel Abdominal Scoring System.
Am J Gastroenterol
; 116(9): 1929-1937, 2021 09 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34465695
3.
Randomized Trial of 2 Delayed-Release Formulations of Linaclotide in Patients With Irritable Bowel Syndrome With Constipation.
Am J Gastroenterol
; 116(2): 354-361, 2021 02 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33065589
4.
Intestinal Guanylate Cyclase-C mRNA Expression in Duodenum and Colon of Children.
J Pediatr Gastroenterol Nutr
; 73(6): 703-709, 2021 12 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34508047
5.
Pharmacologic properties, metabolism, and disposition of linaclotide, a novel therapeutic peptide approved for the treatment of irritable bowel syndrome with constipation and chronic idiopathic constipation.
J Pharmacol Exp Ther
; 344(1): 196-206, 2013 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-23090647
6.
Randomised clinical trial: effects of MD-7246 on irritable bowel syndrome with diarrhoea.
Aliment Pharmacol Ther
; 57(2): 192-204, 2023 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36324245
7.
Fatty acid amide hydrolase (FAAH) inhibition reduces L-3,4-dihydroxyphenylalanine-induced hyperactivity in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned non-human primate model of Parkinson's disease.
J Pharmacol Exp Ther
; 336(2): 423-30, 2011 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-20966038
8.
Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit.
Eur J Pharmacol
; 649(1-3): 328-35, 2010 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20863829
9.
Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract.
Life Sci
; 86(19-20): 760-5, 2010 May 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-20307554
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