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1.
mGlu5 positive allosteric modulation normalizes synaptic plasticity defects and motor phenotypes in a mouse model of Rett syndrome.
Hum Mol Genet
; 25(10): 1990-2004, 2016 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26936821
2.
Heterotropic activation of the midazolam hydroxylase activity of CYP3A by a positive allosteric modulator of mGlu5: in vitro to in vivo translation and potential impact on clinically relevant drug-drug interactions.
Drug Metab Dispos
; 41(12): 2066-75, 2013 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-24003250
3.
Discovery and SAR of a novel series of non-MPEP site mGlu5 PAMs based on an aryl glycine sulfonamide scaffold.
Bioorg Med Chem Lett
; 22(24): 7388-92, 2012 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23142615
4.
Optimization of an ether series of mGlu5 positive allosteric modulators: molecular determinants of MPEP-site interaction crossover.
Bioorg Med Chem Lett
; 22(20): 6481-5, 2012 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22981332
5.
Novel 2-N,N-dimethylaminomethyl-2,3,3a,12b-tetrahydrodibenzo[b,f]furo[2,3-d]oxepin derivatives displaying combined norepinephrine reuptake inhibition and 5-HT2A/2C receptor antagonism.
Bioorg Med Chem Lett
; 15(11): 2898-901, 2005 Jun 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-15911276
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