Detalles de la búsqueda
1.
Cell-permeant and photocleavable chemical inducer of dimerization.
Angew Chem Int Ed Engl
; 53(18): 4717-20, 2014 Apr 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-24677313
2.
Investigation of morpholine isosters for the development of a potent, selective and metabolically stable mTOR kinase inhibitor.
Eur J Med Chem
; 248: 115038, 2023 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-36634458
3.
Brain-penetrant PQR620 mTOR and PQR530 PI3K/mTOR inhibitor reduce huntingtin levels in cell models of HD.
Neuropharmacology
; 162: 107812, 2020 01 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31622602
4.
4-(Difluoromethyl)-5-(4-((3R,5S)-3,5-dimethylmorpholino)-6-((R)-3-methylmorpholino)-1,3,5-triazin-2-yl)pyridin-2-amine (PQR626), a Potent, Orally Available, and Brain-Penetrant mTOR Inhibitor for the Treatment of Neurological Disorders.
J Med Chem
; 63(22): 13595-13617, 2020 11 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-33166139
5.
Site-specific, covalent labeling of recombinant antibody fragments via fusion to an engineered version of 6-O-alkylguanine DNA alkyltransferase.
Bioconjug Chem
; 20(5): 1010-5, 2009 May 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-19388673
6.
Total syntheses of amphidinolides B1, B4, G1, H1 and structure revision of amphidinolide H2.
Chemistry
; 15(16): 3983-4010, 2009.
Artículo
en Inglés
| MEDLINE | ID: mdl-19241433
7.
An engineered protein tag for multiprotein labeling in living cells.
Chem Biol
; 15(2): 128-36, 2008 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-18291317
8.
Preclinical Development of PQR514, a Highly Potent PI3K Inhibitor Bearing a Difluoromethyl-Pyrimidine Moiety.
ACS Med Chem Lett
; 10(10): 1473-1479, 2019 Oct 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31620236
9.
A Conformational Restriction Strategy for the Identification of a Highly Selective Pyrimido-pyrrolo-oxazine mTOR Inhibitor.
J Med Chem
; 62(18): 8609-8630, 2019 09 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-31465220
10.
The Novel TORC1/2 Kinase Inhibitor PQR620 Has Anti-Tumor Activity in Lymphomas as a Single Agent and in Combination with Venetoclax.
Cancers (Basel)
; 11(6)2019 Jun 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-31167506
11.
(S)-4-(Difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine (PQR530), a Potent, Orally Bioavailable, and Brain-Penetrable Dual Inhibitor of Class I PI3K and mTOR Kinase.
J Med Chem
; 62(13): 6241-6261, 2019 07 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-31244112
12.
The novel, catalytic mTORC1/2 inhibitor PQR620 and the PI3K/mTORC1/2 inhibitor PQR530 effectively cross the blood-brain barrier and increase seizure threshold in a mouse model of chronic epilepsy.
Neuropharmacology
; 140: 107-120, 2018 09 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30081001
13.
Discovery and Preclinical Characterization of 5-[4,6-Bis({3-oxa-8-azabicyclo[3.2.1]octan-8-yl})-1,3,5-triazin-2-yl]-4-(difluoromethyl)pyridin-2-amine (PQR620), a Highly Potent and Selective mTORC1/2 Inhibitor for Cancer and Neurological Disorders.
J Med Chem
; 61(22): 10084-10105, 2018 11 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-30359003
14.
PQR309 Is a Novel Dual PI3K/mTOR Inhibitor with Preclinical Antitumor Activity in Lymphomas as a Single Agent and in Combination Therapy.
Clin Cancer Res
; 24(1): 120-129, 2018 01 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29066507
15.
Thiophenol-mediated 1,5-hydrogen transfer for the preparation of pyrrolizidines, indolizidines, and related compounds.
Org Lett
; 9(21): 4375-8, 2007 Oct 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-17887768
16.
A concise synthesis of the Pennsylvania Green fluorophore and labeling of intracellular targets with O6-benzylguanine derivatives.
Org Lett
; 9(19): 3741-4, 2007 Sep 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-17705395
17.
5-(4,6-Dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine (PQR309), a Potent, Brain-Penetrant, Orally Bioavailable, Pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in Oncology.
J Med Chem
; 60(17): 7524-7538, 2017 09 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-28829592
18.
Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention.
Nat Commun
; 8: 14683, 2017 03 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-28276440
19.
Highly diastereoselective formation of spirocyclic compounds via 1,5-hydrogen transfer: a total synthesis of (-)-erythrodiene.
Org Lett
; 7(19): 4103-6, 2005 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-16146362
20.
Thiophenol-mediated hydrogen atom abstraction: an efficient tin-free procedure for the preparation of cyclopentane derivatives.
Org Lett
; 6(15): 2563-6, 2004 Jul 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-15255691