Detalles de la búsqueda
1.
Highly potent and selective NaV1.7 inhibitors for use as intravenous agents and chemical probes.
Bioorg Med Chem Lett
; 27(21): 4805-4811, 2017 11 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29029933
2.
A Second-Generation Oral SARS-CoV-2 Main Protease Inhibitor Clinical Candidate for the Treatment of COVID-19.
J Med Chem
; 2024 Apr 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-38687966
3.
PF-04859989 as a template for structure-based drug design: identification of new pyrazole series of irreversible KAT II inhibitors with improved lipophilic efficiency.
Bioorg Med Chem Lett
; 23(7): 1961-6, 2013 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23466229
4.
A general strategy for the synthesis of cyclic N-aryl hydroxamic acids via partial nitro group reduction.
J Org Chem
; 76(9): 3484-97, 2011 May 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-21452845
5.
Discovery tactics to mitigate toxicity risks due to reactive metabolite formation with 2-(2-hydroxyaryl)-5-(trifluoromethyl)pyrido[4,3-d]pyrimidin-4(3h)-one derivatives, potent calcium-sensing receptor antagonists and clinical candidate(s) for the treatment of osteoporosis.
Chem Res Toxicol
; 23(6): 1115-26, 2010 Jun 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-20507089
6.
Synthesis and SAR of 1,2,3,4-tetrahydroisoquinolin-1-ones as novel G-protein-coupled receptor 40 (GPR40) antagonists.
Bioorg Med Chem Lett
; 19(9): 2400-3, 2009 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19346127
7.
Short-acting 5-(trifluoromethyl)pyrido[4,3-d]pyrimidin-4(3H)-one derivatives as orally-active calcium-sensing receptor antagonists.
Bioorg Med Chem Lett
; 19(16): 4555-9, 2009 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19625189
8.
Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain.
J Med Chem
; 61(15): 6779-6800, 2018 08 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-29944371
9.
One-Pot Synthesis of α-Branched N-Acylamines via Titanium-Mediated Condensation of Amides, Aldehydes, and Organometallics.
Org Lett
; 19(5): 1064-1067, 2017 03 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-28199125
10.
Discovery of Clinical Candidate 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of NaV1.7.
J Med Chem
; 60(16): 7029-7042, 2017 08 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-28682065
11.
Diastereoselective synthesis of ß-heteroaryl syn-α-methyl-ß-amino acid derivatives via a double chiral auxiliary approach.
Org Lett
; 15(3): 562-5, 2013 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23343056
12.
Structure-Based Design of Irreversible Human KAT II Inhibitors: Discovery of New Potency-Enhancing Interactions.
ACS Med Chem Lett
; 4(1): 37-40, 2013 Jan 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-24900560
13.
Discovery of Brain-Penetrant, Irreversible Kynurenine Aminotransferase II Inhibitors for Schizophrenia.
ACS Med Chem Lett
; 3(3): 187-92, 2012 Mar 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-24900455
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