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1.
The in vitro and in vivo profile of aclidinium bromide in comparison with glycopyrronium bromide.
Pulm Pharmacol Ther
; 28(2): 114-21, 2014 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-24928173
2.
Pharmacological characterization of abediterol, a novel inhaled ß(2)-adrenoceptor agonist with long duration of action and a favorable safety profile in preclinical models.
J Pharmacol Exp Ther
; 342(2): 497-509, 2012 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-22588259
3.
Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinyl carbamates as potent and long acting muscarinic antagonists.
Bioorg Med Chem Lett
; 21(11): 3457-61, 2011 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21524581
4.
Characterization of aclidinium bromide, a novel inhaled muscarinic antagonist, with long duration of action and a favorable pharmacological profile.
J Pharmacol Exp Ther
; 331(2): 740-51, 2009 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-19710368
5.
Discovery and characterization of 4'-(2-furyl)-N-pyridin-3-yl-4,5'-bipyrimidin-2'-amine (LAS38096), a potent, selective, and efficacious A2B adenosine receptor antagonist.
J Med Chem
; 50(11): 2732-6, 2007 May 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-17469811
6.
Synthesis and structure-activity relationships of novel histamine H1 antagonists: indolylpiperidinyl benzoic acid derivatives.
J Med Chem
; 47(25): 6326-37, 2004 Dec 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-15566302
7.
Aclidinium bromide, a novel long-acting muscarinic antagonist for COPD with improved preclinical renal and urinary safety profile.
Life Sci
; 90(7-8): 301-5, 2012 Feb 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-22213116
8.
Synthesis and biological activity of pyrido[3',2':4,5]furo[3,2-d]pyrimidine derivatives as novel and potent phosphodiesterase type 4 inhibitors.
Eur J Med Chem
; 46(10): 4946-56, 2011 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-21871695
9.
Aclidinium bromide, a new, long-acting, inhaled muscarinic antagonist: in vitro plasma inactivation and pharmacological activity of its main metabolites.
Eur J Pharm Sci
; 39(5): 283-90, 2010 Mar 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-20093184
10.
Synthesis and biological activity of pyrido[3',2':4,5]thieno[3,2-d]pyrimidines as phosphodiesterase type 4 inhibitors.
J Med Chem
; 53(19): 6912-22, 2010 Oct 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-20825218
11.
Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinol esters as potent and long-acting muscarinic antagonists with potential for minimal systemic exposure after inhaled administration: identification of (3R)-3-{[hydroxy(di-2-thienyl)acetyl]oxy}-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide (aclidinium bromide).
J Med Chem
; 52(16): 5076-92, 2009 Aug 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-19653626
12.
A new chemical tool (C0036E08) supports the role of adenosine A(2B) receptors in mediating human mast cell activation.
Biochem Pharmacol
; 76(7): 912-21, 2008 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18687311
13.
Phosphodiesterase 7A1 is expressed in human CD4+ naïve T cells at higher levels than in CD4+ memory cells and is not required during their CD3/CD28-dependent activation.
Cell Immunol
; 242(1): 31-8, 2006 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-17034773
14.
New pyrrolopyrimidin-6-yl benzenesulfonamides: potent A2B adenosine receptor antagonists.
Bioorg Med Chem Lett
; 16(14): 3642-5, 2006 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-16697192
15.
Synthesis and structure-activity relationships of piperidinylpyrrolopyridine derivatives as potent and selective H1 antagonists.
Bioorg Med Chem Lett
; 15(4): 1165-7, 2005 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-15686934
16.
Synthesis and evaluation of some pyrazolo[3,4-d]pyridazinones and analogues as PDE 5 inhibitors potentially useful as peripheral vasodilator agents.
J Enzyme Inhib Med Chem
; 17(4): 227-33, 2002 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-12530475
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