Detalles de la búsqueda
1.
Physiologically relevant fluorescent assay for identification of 17ß-hydroxysteroid dehydrogenase type 10 inhibitors.
J Neurochem
; 167(2): 154-167, 2023 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-37458164
2.
Small-molecule inhibitors of cyclophilin D as potential therapeutics in mitochondria-related diseases.
Med Res Rev
; 42(5): 1822-1855, 2022 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-35575048
3.
RNase T1 Refolding Assay for Determining Mitochondrial Cyclophilin D Activity: A Novel In Vitro Method Applicable in Drug Research and Discovery.
Biochemistry
; 59(17): 1680-1687, 2020 05 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-32275395
4.
Friend or enemy? Review of 17ß-HSD10 and its role in human health or disease.
J Neurochem
; 155(3): 231-249, 2020 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-32306391
5.
Benzothiazolyl Ureas are Low Micromolar and Uncompetitive Inhibitors of 17ß-HSD10 with Implications to Alzheimer's Disease Treatment.
Int J Mol Sci
; 21(6)2020 Mar 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-32192199
6.
Novel Benzothiazole-based Ureas as 17ß-HSD10 Inhibitors, A Potential Alzheimer's Disease Treatment.
Molecules
; 24(15)2019 Jul 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-31362457
7.
1-(Benzo[d]thiazol-2-yl)-3-phenylureas as dual inhibitors of casein kinase 1 and ABAD enzymes for treatment of neurodegenerative disorders.
J Enzyme Inhib Med Chem
; 33(1): 665-670, 2018 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-29536773
8.
Synthesis and evaluation of frentizole-based indolyl thiourea analogues as MAO/ABAD inhibitors for Alzheimer's disease treatment.
Bioorg Med Chem
; 25(3): 1143-1152, 2017 02 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28082069
9.
Design, synthesis and in vitro evaluation of benzothiazole-based ureas as potential ABAD/17ß-HSD10 modulators for Alzheimer's disease treatment.
Bioorg Med Chem Lett
; 26(15): 3675-8, 2016 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27287370
10.
Nanomolar Benzothiazole-Based Inhibitors of 17ß-HSD10 with Cellular Bioactivity.
ACS Med Chem Lett
; 14(12): 1724-1732, 2023 Dec 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-38116418
11.
Development of submicromolar 17ß-HSD10 inhibitors and their in vitro and in vivo evaluation.
Eur J Med Chem
; 258: 115593, 2023 Oct 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-37390508
12.
[Mitochondrial enzyme ABAD and its role in the development and treatment of Alzheimer's disease]. / Mitochondriáilní enzym ABAD a jeho role v rozvoji a lécbe Alzheimerovy nemoci.
Ceska Slov Farm
; 61(4): 144-9, 2012 Aug.
Artículo
en Cs
| MEDLINE | ID: mdl-23251955
13.
[Tacrine and its derivatives in the therapy of Alzheimers disease]. / Takrin a jeho deriváty v terapii Alzheimerovy choroby.
Ceska Slov Farm
; 61(5): 210-21, 2012 Oct.
Artículo
en Cs
| MEDLINE | ID: mdl-23256654
14.
Effects of novel 17ß-hydroxysteroid dehydrogenase type 10 inhibitors on mitochondrial respiration.
Toxicol Lett
; 339: 12-19, 2021 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33359020
15.
New dual ATP-competitive inhibitors of bacterial DNA gyrase and topoisomerase IV active against ESKAPE pathogens.
Eur J Med Chem
; 213: 113200, 2021 Mar 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-33524686
16.
A Perspective on Multi-target Drugs for Alzheimer's Disease.
Trends Pharmacol Sci
; 41(7): 434-445, 2020 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-32448557
17.
Discovery of novel berberine derivatives with balanced cholinesterase and prolyl oligopeptidase inhibition profile.
Eur J Med Chem
; 203: 112593, 2020 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32688201
18.
Exploring the Chemical Space of Benzothiazole-Based DNA Gyrase B Inhibitors.
ACS Med Chem Lett
; 11(12): 2433-2440, 2020 Dec 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-33329764
19.
A Systematic Review on Donepezil-based Derivatives as Potential Cholinesterase Inhibitors for Alzheimer's Disease.
Curr Med Chem
; 26(30): 5625-5648, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-29768996
20.
Rational design of novel TLR4 ligands by in silico screening and their functional and structural characterization in vitro.
Eur J Med Chem
; 146: 38-46, 2018 Feb 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-29407964