Detalles de la búsqueda
1.
Identification of benzothiazole derived monosaccharides as potent, selective, and orally bioavailable inhibitors of human and mouse galectin-3; a rare example of using a S···O binding interaction for drug design.
Bioorg Med Chem
; 101: 117638, 2024 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-38394996
2.
Molecular mechanism of interspecies differences in the binding affinity of TD139 to Galectin-3.
Glycobiology
; 31(10): 1390-1400, 2021 11 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-34228782
3.
Design and exploration of C-3 benzoic acid bioisosteres and alkyl replacements in the context of GSK3532795 (BMS-955176) that exhibit broad spectrum HIV-1 maturation inhibition.
Bioorg Med Chem Lett
; 36: 127823, 2021 03 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33508465
4.
Epitope and Paratope Mapping of PD-1/Nivolumab by Mass Spectrometry-Based Hydrogen-Deuterium Exchange, Cross-linking, and Molecular Docking.
Anal Chem
; 92(13): 9086-9094, 2020 07 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-32441507
5.
An Integrated Approach for Determining a Protein-Protein Binding Interface in Solution and an Evaluation of Hydrogen-Deuterium Exchange Kinetics for Adjudicating Candidate Docking Models.
Anal Chem
; 91(24): 15709-15717, 2019 12 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-31710208
6.
Orthogonal Mass Spectrometry-Based Footprinting for Epitope Mapping and Structural Characterization: The IL-6 Receptor upon Binding of Protein Therapeutics.
Anal Chem
; 89(14): 7742-7749, 2017 07 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-28621526
7.
Discovery and initial optimization of alkoxyanthranilic acid derivatives as inhibitors of HCV NS5B polymerase.
Bioorg Med Chem Lett
; 27(2): 295-298, 2017 01 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27908764
8.
Synthesis and SAR of calcitonin gene-related peptide (CGRP) antagonists containing substituted aryl-piperazines and piperidines.
Bioorg Med Chem Lett
; 26(4): 1229-32, 2016 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26832218
9.
C-3 benzoic acid derivatives of C-3 deoxybetulinic acid and deoxybetulin as HIV-1 maturation inhibitors.
Bioorg Med Chem
; 24(8): 1757-70, 2016 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26968652
10.
Mechanism of inhibition for BMS-791325, a novel non-nucleoside inhibitor of hepatitis C virus NS5B polymerase.
J Biol Chem
; 289(48): 33456-68, 2014 Nov 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-25301950
11.
Discovery of D1 Dopamine Receptor Positive Allosteric Modulators: Characterization of Pharmacology and Identification of Residues that Regulate Species Selectivity.
J Pharmacol Exp Ther
; 354(3): 340-9, 2015 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-26109678
12.
Synthesis and SAR studies of novel heteroaryl fused tetracyclic indole-diamide compounds: potent allosteric inhibitors of the hepatitis C virus NS5B polymerase.
Bioorg Med Chem Lett
; 22(8): 2866-71, 2012 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22424979
13.
Identification of Monosaccharide Derivatives as Potent, Selective, and Orally Bioavailable Inhibitors of Human and Mouse Galectin-3.
J Med Chem
; 65(16): 11084-11099, 2022 08 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-35969688
14.
SAR studies on a series of N-benzyl-4-heteroaryl-1-(phenylsulfonyl)piperazine-2-carboxamides: potent inhibitors of the polymerase enzyme (NS5B) of the hepatitis C virus.
Bioorg Med Chem Lett
; 21(10): 3142-7, 2011 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21450465
15.
The synthesis and evaluation of a novel class of (E)-3-(1-cyclohexyl-1H-pyrazol-3-yl)-2-methylacrylic acid hepatitis C virus polymerase NS5B inhibitors.
Bioorg Med Chem Lett
; 21(10): 2869-72, 2011 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21507645
16.
Investigation of the mode of binding of a novel series of N-benzyl-4-heteroaryl-1-(phenylsulfonyl)piperazine-2-carboxamides to the hepatitis C virus polymerase.
Bioorg Med Chem Lett
; 21(8): 2212-5, 2011 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21441029
17.
Syntheses and initial evaluation of a series of indolo-fused heterocyclic inhibitors of the polymerase enzyme (NS5B) of the hepatitis C virus.
Bioorg Med Chem Lett
; 21(10): 2925-9, 2011 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21486696
18.
Synthesis, Structure-Activity Relationships, and In Vivo Evaluation of Novel Tetrahydropyran-Based Thiodisaccharide Mimics as Galectin-3 Inhibitors.
J Med Chem
; 64(10): 6634-6655, 2021 05 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-33988358
19.
MORPH: a new tool for ligand design.
J Chem Inf Model
; 50(6): 1159-64, 2010 Jun 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-20481489
20.
Resistance profile of the HIV-1 maturation inhibitor GSK3532795 in vitro and in a clinical study.
PLoS One
; 14(10): e0224076, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-31622432