Detalles de la búsqueda
1.
Dendritic Pyridine-Imine Copper Complexes as Metallo-Drugs.
Molecules
; 29(8)2024 Apr 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-38675623
2.
Further Insights into the Oxidative Pathway of Thiocarbonyl-Type Antitubercular Prodrugs: Ethionamide, Thioacetazone, and Isoxyl.
Chem Res Toxicol
; 34(8): 1879-1889, 2021 08 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-34319702
3.
Pentacyanoferrate(II) complex of pyridine-4- and pyrazine-2-hydroxamic acid as source of HNO: investigation of anti-tubercular and vasodilation activities.
J Biol Inorg Chem
; 25(6): 887-901, 2020 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-32728907
4.
Involvement of Pazopanib and Sunitinib Aldehyde Reactive Metabolites in Toxicity and Drug-Drug Interactions in Vitro and in Patient Samples.
Chem Res Toxicol
; 33(1): 181-190, 2020 01 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-31535851
5.
Ethionamide biomimetic activation and an unprecedented mechanism for its conversion into active and non-active metabolites.
Org Biomol Chem
; 14(37): 8848-8858, 2016 Sep 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-27714216
6.
Crystal structure of the enoyl-ACP reductase of Mycobacterium tuberculosis (InhA) in the apo-form and in complex with the active metabolite of isoniazid pre-formed by a biomimetic approach.
J Struct Biol
; 190(3): 328-37, 2015 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-25891098
7.
Phenyl dialkynylcarbinols, a Bioinspired Series of Synthetic Antitumor Acetylenic Lipids.
J Med Chem
; 66(20): 13918-13945, 2023 10 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-37816126
8.
Cross-docking study on InhA inhibitors: a combination of Autodock Vina and PM6-DH2 simulations to retrieve bio-active conformations.
Org Biomol Chem
; 10(31): 6341-9, 2012 Aug 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-22751934
9.
SDR enzymes oxidize specific lipidic alkynylcarbinols into cytotoxic protein-reactive species.
Elife
; 112022 05 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-35535493
10.
Chemical synthesis, biological evaluation and structure-activity relationship analysis of azaisoindolinones, a novel class of direct enoyl-ACP reductase inhibitors as potential antimycobacterial agents.
Bioorg Med Chem
; 19(21): 6225-32, 2011 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21975068
11.
A divergent mode of activation of a nitrosyl iron complex with unusual antiangiogenic activity.
J Inorg Biochem
; 210: 111133, 2020 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-32619898
12.
An overview on crystal structures of InhA protein: Apo-form, in complex with its natural ligands and inhibitors.
Eur J Med Chem
; 146: 318-343, 2018 Feb 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-29407960
13.
Metalloporphyrin-Catalyzed Oxidation of Sunitinib and Pazopanib, Two Anticancer Tyrosine Kinase Inhibitors: Evidence for New Potentially Toxic Metabolites.
J Med Chem
; 61(17): 7849-7860, 2018 09 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-30102538
14.
Synthesis and mechanistic investigation of iron(II) complexes of isoniazid and derivatives as a redox-mediated activation strategy for anti-tuberculosis therapy.
J Inorg Biochem
; 179: 71-81, 2018 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-29175704
15.
Update of Antitubercular Prodrugs from a Molecular Perspective: Mechanisms of Action, Bioactivation Pathways, and Associated Resistance.
ChemMedChem
; 12(20): 1657-1676, 2017 10 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-28921911
16.
Radical trapping properties of imidazolyl nitrones.
Free Radic Res
; 40(1): 11-20, 2006 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-16298755
17.
Evaluation of the inhibitory activity of (aza)isoindolinone-type compounds: toward in vitro InhA action, Mycobacterium tuberculosis growth and mycolic acid biosynthesis.
Chem Biol Drug Des
; 88(5): 740-755, 2016 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-27301022
18.
Design, synthesis and evaluation of new GEQ derivatives as inhibitors of InhA enzyme and Mycobacterium tuberculosis growth.
Eur J Med Chem
; 101: 218-35, 2015 Aug 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-26142487
19.
2-substituted-3H-indol-3-one-1-oxides: preparation and radical trapping properties.
Free Radic Res
; 38(5): 459-71, 2004 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-15293553
20.
Camphor-Derived, Chelating Auxiliaries for the Highly Diastereoselective Intermolecular Pauson-Khand Reaction: Experimental and Computational Studies.
J Org Chem
; 63(20): 7037-7052, 1998 Oct 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-11672330