Detalles de la búsqueda
1.
Marinopyrrole derivatives with sulfide spacers as selective disruptors of Mcl-1 binding to pro-apoptotic protein Bim.
Mar Drugs
; 12(8): 4311-25, 2014 Jul 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-25076060
2.
The BH3 alpha-helical mimic BH3-M6 disrupts Bcl-X(L), Bcl-2, and MCL-1 protein-protein interactions with Bax, Bak, Bad, or Bim and induces apoptosis in a Bax- and Bim-dependent manner.
J Biol Chem
; 286(11): 9382-92, 2011 Mar 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-21148306
3.
Synthesis and evaluation of substituted hexahydronaphthalenes as novel inhibitors of the Mcl-1/BimBH3 interaction.
Bioorg Med Chem Lett
; 22(18): 5961-5, 2012 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22901384
4.
Bivalent BET Bromodomain Inhibitors Confer Increased Potency and Selectivity for BRDT via Protein Conformational Plasticity.
J Med Chem
; 65(15): 10441-10458, 2022 08 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-35867655
5.
Differential BET Bromodomain Inhibition by Dihydropteridinone and Pyrimidodiazepinone Kinase Inhibitors.
J Med Chem
; 64(21): 15772-15786, 2021 11 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-34710325
6.
Molecular Basis for the N-Terminal Bromodomain-and-Extra-Terminal-Family Selectivity of a Dual Kinase-Bromodomain Inhibitor.
J Med Chem
; 61(20): 9316-9334, 2018 10 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-30253095
7.
Targeting the BRD4-HOXB13 Coregulated Transcriptional Networks with Bromodomain-Kinase Inhibitors to Suppress Metastatic Castration-Resistant Prostate Cancer.
Mol Cancer Ther
; 17(12): 2796-2810, 2018 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-30242092
8.
Advances of small molecule targeting of kinases.
Curr Opin Chem Biol
; 39: 126-132, 2017 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-28732278
9.
Structural Basis of Wee Kinases Functionality and Inactivation by Diverse Small Molecule Inhibitors.
J Med Chem
; 60(18): 7863-7875, 2017 09 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-28792760
10.
Dual Targeting of WEE1 and PLK1 by AZD1775 Elicits Single Agent Cellular Anticancer Activity.
ACS Chem Biol
; 12(7): 1883-1892, 2017 07 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-28557434
11.
BET Bromodomain Inhibitors with One-Step Synthesis Discovered from Virtual Screen.
J Med Chem
; 60(12): 4805-4817, 2017 06 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-28535045
12.
Potent Dual BET Bromodomain-Kinase Inhibitors as Value-Added Multitargeted Chemical Probes and Cancer Therapeutics.
Mol Cancer Ther
; 16(6): 1054-1067, 2017 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-28336808
13.
Interaction between the retinoblastoma protein and protein phosphatase 1 during the cell cycle.
Methods Mol Biol
; 281: 17-32, 2004.
Artículo
en Inglés
| MEDLINE | ID: mdl-15220519
14.
Acetyl-lysine binding site of bromodomain-containing protein 4 (BRD4) interacts with diverse kinase inhibitors.
ACS Chem Biol
; 9(5): 1160-71, 2014 May 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-24568369
15.
Akt2 and acid ceramidase cooperate to induce cell invasion and resistance to apoptosis.
Cell Cycle
; 12(13): 2024-32, 2013 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23777806
16.
Correction to BET Bromodomain Inhibitors with One-Step Synthesis Discovered from Virtual Screen.
J Med Chem
; 60(14): 6458, 2017 07 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-28696689
17.
Measurement of protein farnesylation and geranylgeranylation in vitro, in cultured cells and in biopsies, and the effects of prenyl transferase inhibitors.
Nat Protoc
; 6(11): 1775-91, 2011 Oct 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-22036881
18.
Targeting protein prenylation for cancer therapy.
Nat Rev Cancer
; 11(11): 775-91, 2011 10 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-22020205
19.
Discovery of a novel proteasome inhibitor selective for cancer cells over non-transformed cells.
Cell Cycle
; 8(12): 1940-51, 2009 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19471122
20.
Blockade of protein geranylgeranylation inhibits Cdk2-dependent p27Kip1 phosphorylation on Thr187 and accumulates p27Kip1 in the nucleus: implications for breast cancer therapy.
Mol Cell Biol
; 29(8): 2254-63, 2009 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-19204084