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1.
Switching the three-component Biginelli-like reaction conditions for the regioselective synthesis of new 2-amino[1,2,4]triazolo[1,5-a]pyrimidines.
Org Biomol Chem
; 22(4): 767-783, 2024 01 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-38167738
2.
A novel N-heterocycles substituted oseltamivir derivatives as potent inhibitors of influenza virus neuraminidase: discovery, synthesis and biological evaluation.
J Enzyme Inhib Med Chem
; 38(1): 2277135, 2023 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-37955306
3.
Discovery of Novel Boron-Containing N-Substituted Oseltamivir Derivatives as Anti-Influenza A Virus Agents for Overcoming N1-H274Y Oseltamivir-Resistant.
Molecules
; 27(19)2022 Sep 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-36234966
4.
A small molecule targeting the interaction between human papillomavirus E7 oncoprotein and cellular phosphatase PTPN14 exerts antitumoral activity in cervical cancer cells.
Cancer Lett
; 571: 216331, 2023 09 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-37532093
5.
Discovery of N-substituted oseltamivir derivatives as novel neuraminidase inhibitors with improved drug resistance profiles and favorable drug-like properties.
Eur J Med Chem
; 252: 115275, 2023 Apr 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-36931117
6.
Iterative Optimization and Structure-Activity Relationship Studies of Oseltamivir Amino Derivatives as Potent and Selective Neuraminidase Inhibitors via Targeting 150-Cavity.
J Med Chem
; 65(17): 11550-11573, 2022 09 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-35939763
7.
Targeted Disruption of E6/p53 Binding Exerts Broad Activity and Synergism with Paclitaxel and Topotecan against HPV-Transformed Cancer Cells.
Cancers (Basel)
; 14(1)2021 Dec 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-35008354
8.
The Dimeric Form of HPV16 E6 Is Crucial to Drive YAP/TAZ Upregulation through the Targeting of hScrib.
Cancers (Basel)
; 13(16)2021 Aug 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-34439242
9.
Discovery of highly potent and selective influenza virus neuraminidase inhibitors targeting 150-cavity.
Eur J Med Chem
; 212: 113097, 2021 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33385836
10.
1,2,4-Triazolo[1,5-a]pyrimidines: Efficient one-step synthesis and functionalization as influenza polymerase PA-PB1 interaction disruptors.
Eur J Med Chem
; 221: 113494, 2021 Oct 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-33962311
11.
Synthesis and characterization of 1,2,4-triazolo[1,5-a]pyrimidine-2-carboxamide-based compounds targeting the PA-PB1 interface of influenza A virus polymerase.
Eur J Med Chem
; 209: 112944, 2021 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33328103
12.
Identification of C5-NH2 Modified Oseltamivir Derivatives as Novel Influenza Neuraminidase Inhibitors with Highly Improved Antiviral Activities and Favorable Druggability.
J Med Chem
; 64(24): 17992-18009, 2021 12 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-34735766
13.
A novel small-molecule inhibitor of the human papillomavirus E6-p53 interaction that reactivates p53 function and blocks cancer cells growth.
Cancer Lett
; 470: 115-125, 2020 02 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31693922
14.
Potent and broad-spectrum cycloheptathiophene-3-carboxamide compounds that target the PA-PB1 interaction of influenza virus RNA polymerase and possess a high barrier to drug resistance.
Antiviral Res
; 165: 55-64, 2019 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30885750
15.
A quantitative LumiFluo assay to test inhibitory compounds blocking p53 degradation induced by human papillomavirus oncoprotein E6 in living cells.
Sci Rep
; 8(1): 6020, 2018 04 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-29662081
16.
Structure-Based Optimization of N-Substituted Oseltamivir Derivatives as Potent Anti-Influenza A Virus Agents with Significantly Improved Potency against Oseltamivir-Resistant N1-H274Y Variant.
J Med Chem
; 61(22): 9976-9999, 2018 11 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-30365885
17.
Optimization of N-Substituted Oseltamivir Derivatives as Potent Inhibitors of Group-1 and -2 Influenza A Neuraminidases, Including a Drug-Resistant Variant.
J Med Chem
; 61(14): 6379-6397, 2018 Jul 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-29965752
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