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1.
Novel estrone mimetics with high 17beta-HSD1 inhibitory activity.
Bioorg Med Chem
; 18(10): 3494-505, 2010 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20413314
2.
The role of the heterocycle in bis(hydroxyphenyl)triazoles for inhibition of 17beta-Hydroxysteroid Dehydrogenase (17beta-HSD) type 1 and type 2.
Mol Cell Endocrinol
; 301(1-2): 212-5, 2009 Mar 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-18848601
3.
Design, synthesis and biological evaluation of bis(hydroxyphenyl) azoles as potent and selective non-steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) for the treatment of estrogen-dependent diseases.
Bioorg Med Chem
; 16(12): 6423-35, 2008 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18514529
4.
Treatment of estrogen-dependent diseases: Design, synthesis and profiling of a selective 17ß-HSD1 inhibitor with sub-nanomolar IC50 for a proof-of-principle study.
Eur J Med Chem
; 127: 944-957, 2017 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27852458
5.
Towards the evaluation in an animal disease model: Fluorinated 17ß-HSD1 inhibitors showing strong activity towards both the human and the rat enzyme.
Eur J Med Chem
; 103: 56-68, 2015 Oct 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-26322835
6.
Inhibition of 17ß-HSD1: SAR of bicyclic substituted hydroxyphenylmethanones and discovery of new potent inhibitors with thioether linker.
Eur J Med Chem
; 82: 394-406, 2014 Jul 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-24929290
7.
Hydroxybenzothiazoles as new nonsteroidal inhibitors of 17ß-hydroxysteroid dehydrogenase type 1 (17ß-HSD1).
PLoS One
; 7(1): e29252, 2012.
Artículo
en Inglés
| MEDLINE | ID: mdl-22242164
8.
Selective inhibition of 17beta-hydroxysteroid dehydrogenase type 1 (17betaHSD1) reduces estrogen responsive cell growth of T47-D breast cancer cells.
J Steroid Biochem Mol Biol
; 114(3-5): 200-6, 2009 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-19429452
9.
New insights into the SAR and binding modes of bis(hydroxyphenyl)thiophenes and -benzenes: influence of additional substituents on 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) inhibitory activity and selectivity.
J Med Chem
; 52(21): 6724-43, 2009 Nov 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-19831396
10.
Design, synthesis, biological evaluation and pharmacokinetics of bis(hydroxyphenyl) substituted azoles, thiophenes, benzenes, and aza-benzenes as potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1).
J Med Chem
; 51(21): 6725-39, 2008 Nov 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-18855374
11.
Substituted 6-phenyl-2-naphthols. Potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1): design, synthesis, biological evaluation, and pharmacokinetics.
J Med Chem
; 51(15): 4685-98, 2008 Aug 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-18630892
12.
Aging reduces the efficacy of estrogen substitution to attenuate cardiac hypertrophy in female spontaneously hypertensive rats.
Hypertension
; 48(4): 579-86, 2006 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-16940216
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