Detalles de la búsqueda
1.
Inhibition of fatty acid synthase with FT-4101 safely reduces hepatic de novo lipogenesis and steatosis in obese subjects with non-alcoholic fatty liver disease: Results from two early-phase randomized trials.
Diabetes Obes Metab
; 23(3): 700-710, 2021 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-33289350
2.
Acetyl-CoA Carboxylase Inhibition Reverses NAFLD and Hepatic Insulin Resistance but Promotes Hypertriglyceridemia in Rodents.
Hepatology
; 68(6): 2197-2211, 2018 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-29790582
3.
Dose-dependent quantitative effects of acute fructose administration on hepatic de novo lipogenesis in healthy humans.
Am J Physiol Endocrinol Metab
; 315(1): E126-E132, 2018 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29558206
4.
Intestinal bile acid sequestration improves glucose control by stimulating hepatic miR-182-5p in type 2 diabetes.
Am J Physiol Gastrointest Liver Physiol
; 315(5): G810-G823, 2018 11 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30160993
5.
Acetyl-coenzyme A carboxylase inhibition reduces de novo lipogenesis in overweight male subjects: A randomized, double-blind, crossover study.
Hepatology
; 66(2): 324-334, 2017 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-28470676
6.
Identifying nonalcoholic fatty liver disease patients with active fibrosis by measuring extracellular matrix remodeling rates in tissue and blood.
Hepatology
; 65(1): 78-88, 2017 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27706836
7.
Altered subcutaneous abdominal adipose tissue lipid synthesis in obese, insulin-resistant humans.
Am J Physiol Endocrinol Metab
; 305(8): E999-E1006, 2013 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23982159
8.
Insulin and glucose metabolism with olanzapine and a combination of olanzapine and samidorphan: exploratory phase 1 results in healthy volunteers.
Neuropsychopharmacology
; 47(3): 696-703, 2022 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-34887529
9.
Organic Anion Transporting Polypeptide Inhibition Dramatically Increases Plasma Exposure but not Pharmacodynamic Effect nor Inferred Hepatic Intracellular Exposure of Firsocostat.
Clin Pharmacol Ther
; 109(5): 1334-1341, 2021 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-33141923
10.
Dietary sugar restriction reduces hepatic de novo lipogenesis in adolescent boys with fatty liver disease.
J Clin Invest
; 131(24)2021 12 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34907907
11.
Sotagliflozin Decreases Postprandial Glucose and Insulin Concentrations by Delaying Intestinal Glucose Absorption.
J Clin Endocrinol Metab
; 105(4)2020 04 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31837264
12.
Dietary sucrose is essential to the development of liver injury in the methionine-choline-deficient model of steatohepatitis.
J Lipid Res
; 50(10): 2072-82, 2009 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-19295183
13.
Beta cell secretion of miR-375 to HDL is inversely associated with insulin secretion.
Sci Rep
; 9(1): 3803, 2019 03 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-30846744
14.
Human sebum requires de novo lipogenesis, which is increased in acne vulgaris and suppressed by acetyl-CoA carboxylase inhibition.
Sci Transl Med
; 11(492)2019 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31092695
15.
Uncovering a Predictive Molecular Signature for the Onset of NASH-Related Fibrosis in a Translational NASH Mouse Model.
Cell Mol Gastroenterol Hepatol
; 5(1): 83-98.e10, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-29276754
16.
Measurement of protein turnover rates by heavy water labeling of nonessential amino acids.
Biochim Biophys Acta
; 1760(5): 730-44, 2006 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-16567052
17.
Specific Macronutrients Exert Unique Influences on the Adipose-Liver Axis to Promote Hepatic Steatosis in Mice.
Cell Mol Gastroenterol Hepatol
; 4(2): 223-236, 2017 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-28649594
18.
Isocaloric manipulation of macronutrients within a high-carbohydrate/moderate-fat diet induces unique effects on hepatic lipogenesis, steatosis and liver injury.
J Nutr Biochem
; 29: 12-20, 2016 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-26895660
19.
Potential mechanisms leading to the abnormal lipid profile in patients with rheumatoid arthritis versus healthy volunteers and reversal by tofacitinib.
Arthritis Rheumatol
; 67(3): 616-25, 2015 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-25470338
20.
MicroRNA-29 fine-tunes the expression of key FOXA2-activated lipid metabolism genes and is dysregulated in animal models of insulin resistance and diabetes.
Diabetes
; 63(9): 3141-8, 2014 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-24722248